Evidence map›Paper›PMID 28493231›Full record

SynthesisSchmerz (Berlin, Germany)2017

[Drug therapy of fibromyalgia syndrome : Updated guidelines 2017 and overview of systematic review articles].

C Sommer, R Alten, K-J Bär, M Bernateck, W Brückle, E Friedel, P Henningsen, F Petzke, T Tölle, N Üçeyler and 2 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Schmerz (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Cannabinoids in Pain Management and Palliative Medicine.Deutsches Arzteblatt international · 2017
    Pooled it
  3. Pooled it
  4. Article
  5. Patient Version of Guideline for Fibromyalgia (2025 Edition).Journal of evidence-based medicine · 2025
    Article
  6. Article
  7. Article
  8. [Procedures of complementary medicine in rheumatology].Zeitschrift fur Rheumatologie · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Adherence to Clinical Guidelines for Fibromyalgia: Help or Hindrance?Canadian journal of pain = Revue canadienne de la douleur · 2023
    Article
  15. Review
  16. Article
  17. Disentangling Diagnosis and Management of Fibromyalgia.Journal of rheumatic diseases · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

C SommerNeurologische Klinik, Universitätsklinikum Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Deutschland. sommer@uni-wuerzburg.de.
R AltenSchlosspark-Klinik, Universitätsmedizin Berlin, Berlin, Deutschland.
K-J BärKlinik für Psychiatrie und Psychotherapie, Friedrich-Schiller-Universität Jena, Jena, Deutschland.
M BernateckZentrum für Schmerzmedizin, Hannover, Deutschland.
W BrückleRheumatologikum, Hannover, Deutschland.
E FriedelMedis Research GmbH, Bad Kissingen, Deutschland.
P HenningsenKlinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Technische Universität München, München, Deutschland.
F PetzkeSchmerzmedizin, Klinik für Anästhesiologie, Universitätsmedizin Göttingen, Göttingen, Deutschland.
T TölleKlinik für Neurologie, Technische Universität München, München, Deutschland.
N ÜçeylerNeurologische Klinik, Universitätsklinikum Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Deutschland.
A WinkelmannKlinik und Poliklinik für Orthopädie, Physikalische Medizin und Rehabilitation, Klinikum der Universität München, München, Deutschland.
W HäuserKlinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Technische Universität München, München, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was scheduled for April 2017.

methodsThe guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest. A literature search for systematic reviews of randomized controlled drug trials from December 2010 to May 2016 was performed in the Cochrane library, MEDLINE, PsycINFO and Scopus databases. Levels of evidence were assigned according to the classification system of the Oxford Centre for Evidence-Based Medicine version 2009. The strength of recommendations was achieved by multiple step formalized procedures to reach a consensus. Efficacy, risks, patient preferences and applicability of available therapies were weighed up against each other. The guidelines were reviewed and approved by the board of directors of the societies engaged in the development of the guidelines. RESULTS AND

conclusionAmitriptyline and duloxetine are recommended in the case of comorbid depressive disorders or generalized anxiety disorder and pregabalin in the case of generalized anxiety disorder. Off-label use of duloxetine and pregabalin can be considered if there are no comorbid mental disorders or no generalized anxiety disorder. Strong opioids are not recommended.

Indexed as

Practice Guidelines as TopicAmitriptylineAnxiety DisordersComorbidityDepressive DisorderDuloxetine HydrochlorideEvidence-Based MedicineFibromyalgiaGermanyHumansPregabalinRandomized Controlled Trials as TopicSocieties, MedicalAmitriptylineDuloxetine HydrochloridePregabalinDrug therapyFibromyalgia syndromeGuidelinesMedicine, evidence-basedReview, systematic

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.