SynthesisSchmerz (Berlin, Germany)2017
[Etiology and pathophysiology of fibromyalgia syndrome : Updated guidelines 2017, overview of systematic review articles and overview of studies on small fiber neuropathy in FMS subgroups].
Synthesis in Schmerz (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Mirtazapine for fibromyalgia in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia.The Cochrane database of systematic reviews · 2018Pooled it
- [General treatment principles, coordination of care and patient education in fibromyalgia syndrome : Updated guidelines 2017 and overview of systematic review articles].Schmerz (Berlin, Germany) · 2017Pooled it
- Patient Version of Guideline for Fibromyalgia (2025 Edition).Journal of evidence-based medicine · 2025Article
- [Etiological factors in chronic widespread pain and/or fibromyalgia syndrome: subjective perspectives of patients, general practitioners and psychotherapists : A pilot study].Schmerz (Berlin, Germany) · 2025Article
- Pain Phenotype in Knee Osteoarthritis: Implications for Mechanism-Based Therapy.Orthopaedic surgery · 2025Review
- Effect of Repetitive Transcranial Magnetic Stimulation on the Symptoms and Brain Imaging in Patients with Fibromyalgia Syndrome: A Randomized Controlled Pilot Trial.Pain and therapy · 2025Article
- Social Connection and Chronic Pain: A Cohort Study to Explore the Association of Social Isolation and Loneliness with Chronic Pain Among Older Adults in China.Journal of pain research · 2025Article
- Article
- Post-COVID Patients With New-Onset Chronic Pain 2 Years After Infection: Cross-Sectional Study.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023Article
- Mild Water-Filtered Infrared-A Whole-Body Hyperthermia Reduces Pain in Patients with Fibromyalgia Syndrome-A Randomized Sham-Controlled Trial.Journal of clinical medicine · 2023Article
- Central and peripheral mechanisms of pain in fibromyalgia: scoping review protocol.Rheumatology international · 2023Article
- Methylation factors as biomarkers of fibromyalgia.Annals of translational medicine · 2023Article
- Fibromyalgia, Pain, and Physical Activity: A Bibliometric Analysis.International journal of environmental research and public health · 2023Article
- Fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes.PloS one · 2022Article
- The Role of Nutrient Supplementation in the Management of Chronic Pain in Fibromyalgia: A Narrative Review.Pain and therapy · 2021Review
- Correlating cognition and cortical excitability with pain in fibromyalgia: a case control study.Advances in rheumatology (London, England) · 2021Article
- Review
- Facts and myths pertaining to fibromyalgia.Dialogues in clinical neuroscience · 2018Review
- [Stress-induced hyperalgesia].Schmerz (Berlin, Germany) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was planned for April 2017.
methodsThe guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest. A systematic search of the literature from December 2010 to May 2016 was performed in the Cochrane library, MEDLINE, PsycINFO and Scopus databases. Prospective population-based studies and systematic reviews with meta-analyses of case control studies were taken into consideration for the statements. Levels of evidence were assigned according to the classification system of the Oxford Centre for Evidence-Based Medicine version 2009. The statements were generated by multiple step formalized procedures. The guidelines were reviewed and approved by the board of directors of the societies engaged in the development of the guidelines.
resultsCurrent data do not enable identification of distinct factors in the etiology and pathophysiology of fibromyalgia syndrome. Fibromyalgia syndrome can be associated with inflammatory rheumatic diseases, gene polymorphisms, life style factors (e.g. smoking, obesity and lack of physical activity), depressive disorders as well as physical and sexual abuse in childhood and adulthood.
conclusionFibromyalgia syndrome is most probably the end result of various pathogenetic factors and pathophysiological mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.