Evidence map›Paper›PMID 28493080›Full record

ArticleInflammation2017

Therapeutic Action of Honokiol on Postoperative Ileus via Downregulation of iNOS Gene Expression.

Taiki Mihara, Shoma Mikawa, Noriyuki Kaji, Mari Endo, Tetsuro Oikawa, Jan Tong-Rong, Hiroshi Ozaki, Masatoshi Hori

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. [Honokiol reduces doxorubicin-induced cardiotoxicityNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Taiki MiharaDepartment of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
Shoma MikawaDepartment of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
Noriyuki KajiDepartment of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
Mari EndoDepartment of Clinical Research, Oriental Medicine Research Center, Tokyo, 108-8642, Japan.
Tetsuro OikawaDepartment of Clinical Research, Oriental Medicine Research Center, Tokyo, 108-8642, Japan.
Jan Tong-RongDepartment and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
Hiroshi OzakiDepartment of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
Masatoshi HoriDepartment of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan. ahori@mail.ecc.u-tokyo.ac.jp.
The University of Tokyo · JPNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative ileus is a common complication after intra-abdominal surgery. Nitric oxide produced by macrophages in the inflamed gastrointestinal tract plays a crucial role in the pathogeny of postoperative ileus. Honokiol, extracted from the bark of Magnolia spp., is a natural compound with a biphenolic structure. In the present study, we examined the effect of honokiol on postoperative ileus and discussed its site of action. Postoperative ileus model mice were generated by surgical intestinal manipulation. Mice were administered honokiol (10 mg kg

Indexed as

Allyl CompoundsAnimalsBiphenyl CompoundsCytokinesDown-RegulationGastrointestinal MotilityIleusInflammation MediatorsLeukocytesLignansMacrophages, PeritonealMiceNitric Oxide Synthase Type IIPhenolsPostoperative ComplicationsRNA, MessengerAllyl CompoundsBiphenyl CompoundsCytokineshonokiolInflammation MediatorsLignansNitric Oxide Synthase Type IINos2 protein, mousePhenolsRNA, Messengeranti-inflammationhonokiolmacrophagepostoperative ileus

Identifiers

PMID28493080
OpenAlexW2612970733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.