ArticleCellular and molecular life sciences : CMLS2017
Extracellular vesicles regulate the human osteoclastogenesis: divergent roles in discrete inflammatory arthropathies.
Article in Cellular and molecular life sciences : CMLS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The role of extracellular vesicles in rheumatoid arthritis: a systematic review.Clinical rheumatology · 2021Pooled it
- Exosomal Protein Biomarkers in Arthritis: Deciphering the Inflammatory Profiles of RA and OA.Biomedicines · 2025Article
- Diagnostic and Therapeutic Roles of Extracellular Vesicles and Their Enwrapped ncRNAs in Rheumatoid Arthritis.Journal of inflammation research · 2024Review
- Review
- Receptor activator of nuclear factor-kappa B is enriched in CD9-positive extracellular vesicles released by osteoclasts.Extracellular vesicles and circulating nucleic acids · 2023Article
- Bone marrow-derived exosomes promote inflammation and osteoclast differentiation in high-turnover renal osteodystrophy.Renal failure · 2023Article
- Profiling Blood Serum Extracellular Vesicles in Plaque Psoriasis and Psoriatic Arthritis Patients Reveals Potential Disease Biomarkers.International journal of molecular sciences · 2022Article
- Update on the role of extracellular vesicles in rheumatoid arthritis.Expert reviews in molecular medicine · 2022Review
- Proteomic Changes of Osteoclast Differentiation in Rheumatoid and Psoriatic Arthritis Reveal Functional Differences.Frontiers in immunology · 2022Article
- Exosome: Function and Application in Inflammatory Bone Diseases.Oxidative medicine and cellular longevity · 2021Review
- RANKL and RANK in extracellular vesicles: surprising new players in bone remodeling.Extracellular vesicles and circulating nucleic acids · 2021Article
- Extracellular vesicles in Inflammatory Skin Disorders: from Pathophysiology to Treatment.Theranostics · 2020Review
- Osteoclast Signal Transduction During Bone Metastasis Formation.Frontiers in cell and developmental biology · 2020Review
- Enhanced angiogenic function in response to fibroblasts from psoriatic arthritis synovium compared to rheumatoid arthritis.Arthritis research & therapy · 2019Article
- Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?Stem cell research & therapy · 2019Review
- Comprehensive analyses of long non-coding RNA expression profiles by RNA sequencing and exploration of their potency as biomarkers in psoriatic arthritis patients.BMC immunology · 2019Article
- Extracellular vesicle identification in tooth movement models.Orthodontics & craniofacial research · 2019Article
- Article
- The Role of Exosomes in Bone Remodeling: Implications for Bone Physiology and Disease.Disease markers · 2019Review
- The proteome of extracellular vesicles released by clastic cells differs based on their substrate.PloS one · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveExtracellular vesicles (EVs) are subcellular signalosomes. Although characteristic EV production is associated with numerous physiological and pathological conditions, the effect of blood-derived EVs on bone homeostasis is unknown. Herein we evaluated the role of circulating EVs on human osteoclastogenesis.
methodsBlood samples from healthy volunteers, rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients were collected. Size-based EV sub-fractions were isolated by gravity-driven filtration and differential centrifugation. To investigate the properties of EV samples, resistive pulse sensing technique, transmission electron microscopy, flow cytometry and western blot were performed. CD14
resultsEVs isolated by size-based sub-fractions were characterized as either microvesicles or exosomes (EXO). Healthy (n = 11) and RA-derived (n = 12) EXOs profoundly inhibited osteoclast differentiation (70%, p < 0.01; 65%, p < 0.01, respectively). In contrast, PsA-derived (n = 10) EXOs had a stimulatory effect (75%, p < 0.05). In cross-treatment experiments where EXOs and CD14
conclusionsOur data suggest that blood-derived EXOs are novel regulators of the human osteoclastogenesis and may offer discrete effector function in distinct inflammatory arthropathies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.