ArticleThe American journal of pathology1988
Blastemal cells of nephroblastomatosis complex share an onco-developmental antigen with embryonic kidney and Wilms' tumor. An immunohistochemical study on polysialic acid distribution.
Article in The American journal of pathology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 34 citations in OpenAlex.
- Computed Tomography Image Features under Denoising Algorithm for Benign and Malignant Diagnosis of Renal Parenchymal Tumor.Contrast media & molecular imaging · 2022Article
- The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets.EMBO molecular medicine · 2013Article
- Expression of stem cell markers in the human fetal kidney.PloS one · 2009Article
- Transcript profiling of Wilms tumors reveals connections to kidney morphogenesis and expression patterns associated with anaplasia.Oncogene · 2005Article
- Polysialic acid engineering: synthesis of polysialylated neoglycosphingolipids by using the polysialyltransferase from neuroinvasive Escherichia coli K1.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.Journal of clinical pathology · 1991Article
- Glutathione S-transferase expression in fetal kidney and Wilms' tumour.British journal of cancer · 1990Article
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4 authors at 1 institution in 1 country.
Funding
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Abstract
Previous investigations on polysialic acid of the neural cell adhesion molecule NCAM in human kidney have demonstrated its presence during nephrogenesis in embryonic kidney, absence in normal adult kidney, and reexpression in Wilms' tumor. These data showed that polysialic acid of NCAM is an onco-developmental antigen in human kidney and provided more direct evidence for the metanephric origin of Wilms' tumor. In the present study, five cases of Wilms' tumor associated with nephroblastomatosis complexes were immunohistochemically investigated with a monoclonal antibody for the presence of polysialic acid. Regardless of the type of nephroblastomatosis complex, ie, renal nodular blastema, simple tubular metanephric hamartoma, sclerosing metanephric hamartoma with adenoma, or incipient Wilms' tumor, immunoreactivity for polysialic acid was found in the blastemal cells, but was undetectable in all other structural elements. Because only blastemal cells exhibited a characteristic feature of embryonal differentiating metanephric derivatives, it appears that Wilms' tumor has its origin not exclusively in nodular renal blastema but rather in blastemal cells present in the various forms of nephroblastomatosis complex. The presence of polysialic acid of NCAM in blastemal cells in such lesions indicates that further events in addition to the expression of the embryonic form of this cell adhesion molecule may be involved in the pathogenesis of Wilms' tumor.
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2849302PMC1880816W59570204What OpenQuestion holds
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