Evidence map›Paper›PMID 28492790›Full record

Trial reportBrazilian journal of cardiovascular surgery

Effects of Low-Dose Recombinant Human Brain Natriuretic Peptide on Anterior Myocardial Infarction Complicated by Cardiogenic Shock.

Yesheng Pan, ZhiGang Lu, Jingyu Hang, Shixin Ma, Jian Ma, Meng Wei

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brazilian journal of cardiovascular surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yesheng PanHeart Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
ZhiGang LuHeart Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
Jingyu HangHeart Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
Shixin MaHeart Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
Jian MaHeart Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
Meng WeiHeart Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
Shanghai Sixth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction: The mortality due to cardiogenic shock complicating acute myocardial infarction (AMI) is high even in patients with early revascularization. Infusion of low dose recombinant human brain natriuretic peptide (rhBNP) at the time of AMI is well tolerated and could improve cardiac function.

objective: The objective of this study was to evaluate the hemodynamic effects of rhBNP in AMI patients revascularized by emergency percutaneous coronary intervention (PCI) who developed cardiogenic shock.

methods: A total of 48 patients with acute ST segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock and whose hemodynamic status was improved following emergency PCI were enrolled. Patients were randomly assigned to rhBNP (n=25) and control (n=23) groups. In addition to standard therapy, study group individuals received rhBNP by continuous infusion at 0.005 µg kg-1 min-1 for 72 hours.

results: Baseline characteristics, medications, and peak of cardiac troponin I (cTnI) were similar between both groups. rhBNP treatment resulted in consistently improved pulmonary capillary wedge pressure (PCWP) compared to the control group. Respectively, 7 and 9 patients died in experimental and control groups. No drug-related serious adverse events occurred in either group.

conclusion: When added to standard care in stable patients with cardiogenic shock complicating anterior STEMI, low dose rhBNP improves PCWP and is well tolerated.

Indexed as

AgedAnalysis of VarianceAnterior Wall Myocardial InfarctionBlood PressureFemaleHeart RateHumansIntra-Aortic Balloon PumpingMaleMiddle AgedNatriuretic Peptide, BrainPercutaneous Coronary InterventionPulmonary Wedge PressureRecombinant ProteinsShock, CardiogenicST Elevation Myocardial InfarctionNatriuretic Peptide, BrainRecombinant Proteins

Identifiers

PMID28492790
PMCPMC5409251
OpenAlexW2604714094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.