Evidence map›Paper›PMID 28492524›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2017

Sociodemographic and attitudinal predictors of simultaneous and redundant multiple marker and cell-free DNA screening among women aged ⩾35 years.

A K Lewkowitz, A J Kaimal, K Thao, A O'Leary, O Nseyo, M Kuppermann

Abstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

A K LewkowitzDepartment of Obstetrics &Gynecology, Washington University in St Louis, St Louis, MO, USA.
A J KaimalDepartment of Obstetrics &Gynecology, Massachusetts General Hospital, Boston, MA, USA.
K ThaoDepartment of Obstetrics, Gynecology &Reproductive Sciences, University of California, San Francisco, CA, USA.
A O'LearyDepartment of Obstetrics, Gynecology &Reproductive Sciences, University of California, San Francisco, CA, USA.
O NseyoDepartment of Obstetrics, Gynecology &Reproductive Sciences, University of California, San Francisco, CA, USA.
M KuppermannDepartment of Obstetrics, Gynecology &Reproductive Sciences, University of California, San Francisco, CA, USA.
University of California, San Francisco · USMassachusetts General Hospital · USWashington University in St. Louis · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
NCATS NIH HHS UL1 TR000004
6 · The paper itself

Abstract

objectiveTo identify characteristics associated with undergoing cell-free DNA (cfDNA) and multiple marker screening (MMS) simultaneously or redundantly (after receiving negative results from the first screening test) among women aged ⩾35 years. STUDY

designParticipants presenting for prenatal testing completed a questionnaire that included measures of pregnancy worry and attitudes toward potential testing outcomes; data on prenatal test use was obtained via medical record review. We used multivariable logistic regression to identify factors associated with redundant or simultaneous screening.

resultsAmong 164 participants, 69 (42.1%) had cfDNA redundantly (n=51) to, or simultaneously (n=18) with, MMS. Compared with the 46 MMS-negative women who did not undergo further testing, those who underwent redundant or simultaneous cfDNA/MMS screening were more likely to have annual family incomes >$150 000, to feel having a miscarriage would be worse than having an intellectually disabled child, to desire comprehensive testing for intellectual disability and to have more pregnancy worry.

conclusionProviders who counsel patients on prenatal aneuploidy screening tests should explain the appropriate utilization of these screening tests to avoid unnecessary or minimally informative use of multiple tests.

Indexed as

Health Knowledge, Attitudes, PracticeSocioeconomic FactorsAdultBiomarkersCaliforniaCell-Free Nucleic AcidsCongenital AbnormalitiesFemaleHumansIncomeLogistic ModelsMultivariate AnalysisPregnancyPrenatal DiagnosisProspective StudiesTertiary Care CentersBiomarkersCell-Free Nucleic Acids

Identifiers

PMID28492524
PMCPMC5562526
OpenAlexW2613754146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.