Versatile Methodology for Glycosurfaces: Direct Ligation of Nonderivatized Reducing Saccharides to Poly(pentafluorophenyl acrylate) Grafted Surfaces via Hydrazide Conjugation.

Li Chen, Deborah Leman, Caitlin R Williams, Karson Brooks, Duncan C Krause, Jason Locklin

Abstract read

In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Recent Advances in Polymers Bearing Activated Esters for the Synthesis of Glycopolymers by Postpolymerization Modification.Polymers · 2024
Review
Enzymatic elaboration of oxime-linked glycoconjugates in solution and on liposomes.Journal of materials chemistry. B · 2022
Article
Distinct Mycoplasma pneumoniae Interactions with Sulfated and Sialylated Receptors.Infection and immunity · 2020
Article
Sialylated Receptor Setting Influences Mycoplasma pneumoniae Attachment and Gliding Motility.Molecular microbiology · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li ChenDepartment of Chemistry and College of Engineering, ‡New Materials Institute, and §Department of Microbiology, University of Georgia , Athens, Georgia 30602, United States.

Deborah LemanDepartment of Chemistry and College of Engineering, ‡New Materials Institute, and §Department of Microbiology, University of Georgia , Athens, Georgia 30602, United States.

Caitlin R WilliamsDepartment of Chemistry and College of Engineering, ‡New Materials Institute, and §Department of Microbiology, University of Georgia , Athens, Georgia 30602, United States.

Karson BrooksDepartment of Chemistry and College of Engineering, ‡New Materials Institute, and §Department of Microbiology, University of Georgia , Athens, Georgia 30602, United States.

Duncan C KrauseDepartment of Chemistry and College of Engineering, ‡New Materials Institute, and §Department of Microbiology, University of Georgia , Athens, Georgia 30602, United States.

Jason LocklinDepartment of Chemistry and College of Engineering, ‡New Materials Institute, and §Department of Microbiology, University of Georgia , Athens, Georgia 30602, United States.ORCID 0000-0001-9272-2403

Funding

Human Airway Colonization by Mycoplasma pneumoniaeR01AI110098 · NIAID · UNIVERSITY OF GEORGIA · PI KRAUSE, DUNCAN C · 2014 to 2018

$1.9M

NIAID NIH HHS R01 AI110098

6 · The paper itself

Abstract

In this work, we report a convenient and versatile strategy for surface-grafted glycopolymer constructs with the goal of surface modification that controls the chemical presentation and grafting density of carbohydrate side chains. This approach employs a difunctional hydrazine linker, chemically modified to an active ester containing poly(pentafluorophenyl acrylate) grafted scaffold, to conjugate a variety of saccharides through the reducing end. The successive conjugation steps are carried out under mild conditions and yield high surface densities of sugars, as high as 4.8 nmol·cm

Indexed as

AcrylatesCarbohydratesGlycosylationHumansLectinsSurface PropertiesAcrylatesCarbohydratesLectins

Identifiers

PMID28492327

DOI10.1021/acs.langmuir.7b00779

PMCPMC5833976

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.