ArticleNature communications2017
Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Foliar GR24 and γ-aminobutyric acid modulate redox signaling, root-system architecture, and mineral homeostasis in tellurite-stressed wheat (Plant signaling & behavior · 2026Article
- Article
- Characterization of Tellurite Toxicity toInternational journal of molecular sciences · 2025Article
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- Can Porphyrin-Triphenylphosphonium Conjugates Enhance the Photosensitizer Performance Toward Bacterial Strains?ACS applied bio materials · 2024Article
- Insights into the Synergistic Antibacterial Activity of Silver Nitrate with Potassium Tellurite againstMicrobiology spectrum · 2023Article
- The Klebsiella pneumoniaeInfection and immunity · 2023Article
- Soft-metal(loid)s induce protein aggregation inFrontiers in microbiology · 2023Article
- Tolerance, Adaptation, and Cell Response Elicited byInternational journal of molecular sciences · 2022Article
- Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials.Nano-micro letters · 2022Review
- An exploration of microbial response to stressors with Prof. Claudio C. Vásquez Guzmán.Biological research · 2022Article
- Anaerobic RSH-dependent tellurite reduction contributes to Escherichia coli tolerance against tellurite.Biological research · 2022Article
- Characterization of the Tellurite-Resistance Properties and Identification of the Core Function Genes for Tellurite Resistance inMicroorganisms · 2022Article
- Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation.Acta pharmaceutica Sinica. B · 2021Article
- Broad Spectrum Antibiotic Xanthocillin X Effectively KillsACS central science · 2021Article
- Understanding gold toxicity in aerobically-grown Escherichia coli.Biological research · 2020Article
- Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategies.Microbial cell factories · 2020Article
- Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments.Nature protocols · 2019Article
- Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite.Nature communications · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
The metalloid tellurite is highly toxic to microorganisms. Several mechanisms of action have been proposed, including thiol depletion and generation of hydrogen peroxide and superoxide, but none of them can fully explain its toxicity. Here we use a combination of directed evolution and chemical and biochemical approaches to demonstrate that tellurite inhibits heme biosynthesis, leading to the accumulation of intermediates of this pathway and hydroxyl radical. Unexpectedly, the development of tellurite resistance is accompanied by increased susceptibility to hydrogen peroxide. Furthermore, we show that the heme precursor 5-aminolevulinic acid, which is used as an antimicrobial agent in photodynamic therapy, potentiates tellurite toxicity. Our results define a mechanism of tellurite toxicity and warrant further research on the potential use of the combination of tellurite and 5-aminolevulinic acid in antimicrobial therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.