Evidence map›Paper›PMID 28492279›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression.

Tung-Ping Su, Mu-Hong Chen, Cheng-Ta Li, Wei-Chen Lin, Chen-Jee Hong, Ralitza Gueorguieva, Pei-Chi Tu, Ya-Mei Bai, Chih-Ming Cheng, John H Krystal

Erratum issuedOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 94 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 14 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 14 syntheses or guidelines pooled it, 198 citations in OpenAlex.

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  2. Autism, youth suicide, and psychedelics: A review of the 21st century evidence.Journal of the Chinese Medical Association : JCMA · 2024
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Tung-Ping SuDivision of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Mu-Hong ChenDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Cheng-Ta LiDivision of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Wei-Chen LinDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Chen-Jee HongDivision of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Ralitza GueorguievaDepartment of Biostatistics, School of Public Health, Yale University, New Haven, CT, USA.
Pei-Chi TuDivision of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Ya-Mei BaiDivision of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Chih-Ming ChengDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0001-8334-0438
John H KrystalDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TWYale New Haven Hospital · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
ZIPRASIDONE IN TOURETTES SYNDROME, OBSESSIVE COMPULSIVE &PERVASIVE DEV. DISORDERM01RR000125 · NCRR · YALE UNIVERSITY · PI ALPERN, ROBERT J · 1985 to 2006
$24.1M
NCATS NIH HHS UL1 TR001863NCRR NIH HHS M01 RR000125NCRR NIH HHS UL1 RR024139NIAAA NIH HHS P50 AA012870
6 · The paper itself

Abstract

The antidepressant effects of ketamine are thought to depend on brain-derived neurotrophic factor (BDNF) genotype and dose. The purpose of this study was to characterize the dose-related antidepressant effects of ketamine in patients with treatment-resistant depression drawn from a Chinese population predominately possessing lower activity BDNF genotypes (Val/Met, Met/Met). We conducted a double-blind, randomized, parallel-group, placebo-controlled trial of a single ketamine infusion (saline, 0.2 mg/kg, 0.5 mg/kg). Patients (N=71; BDNF genotype: Val/Val (N=12, 17%), Val/Met (N=40, 56.3%), and Met/Met (N=19, 26.8%)) received mood ratings before infusion, after infusion, and for the subsequent 14 days. Plasma ketamine levels and BDNF genotypes were assessed. This study found a significant dose-related ketamine effect on scores on the Hamilton Depression Rating Scale (HAMD). The responder analysis (>50% reduction from baseline HAMD on at least 2 days between days 2 and 5) also revealed a significant dose-related effect (saline: 12.5%, 0.2 mg/kg: 39.1%; 0.5 mg/kg: 45.8%). This is the first report to our knowledge to demonstrate the dose-related efficacy of R/S-ketamine for treatment-resistant depression and the first to characterize ketamine effects in a genotyped Chinese population in which most (83%) patients possessed at least one copy of the lower functioning Met allele of the BDNF gene.

Indexed as

AdultAntidepressive AgentsAsian PeopleBlood PressureBrain-Derived Neurotrophic FactorDepressive Disorder, Treatment-ResistantDose-Response Relationship, DrugDouble-Blind MethodFemaleHeart RateHumansKetamineMajor Depressive DisorderMaleMiddle AgedPolymorphism, GeneticAntidepressive AgentsBDNF protein, humanBrain-Derived Neurotrophic FactorKetaminenorketamine

Identifiers

PMID28492279
PMCPMC5686503
OpenAlexW2614068273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.