Evidence map›Paper›PMID 28492229›Full record

ArticleNature communications2017

Imaging of pH in vivo using hyperpolarized

Stephan Düwel, Christian Hundshammer, Malte Gersch, Benedikt Feuerecker, Katja Steiger, Achim Buck, Axel Walch, Axel Haase, Steffen J Glaser, Markus Schwaiger and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 118 citations in OpenAlex.

  1. Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using HyperpolarizedAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Preclinical Applications of Magnetic Resonance Imaging in Oncology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  5. Potential Clinical Applications of HyperpolarizedRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  6. Interactions Between Active Matters and Endogenous Fields.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. New Horizons in HyperpolarizedMolecular imaging and biology · 2024
    Article
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Stephan DüwelDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.
Christian HundshammerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.
Malte GerschDepartment of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching, Germany.ORCID 0000-0003-2767-9589
Benedikt FeuereckerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.
Katja SteigerInstitute of Pathology, Technical University of Munich, Trogerstr. 18, 81675 Munich, Germany.ORCID 0000-0002-7269-5433
Achim BuckResearch Unit Analytical Pathology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Axel WalchResearch Unit Analytical Pathology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Axel HaaseInstitute of Medical Engineering, Technical University of Munich, Boltzmannstr. 11, 85748 Garching, Germany.
Steffen J GlaserDepartment of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching, Germany.
Markus SchwaigerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.
Franz SchillingDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.
TUM Klinikum · DETechnical University of Munich · DEHelmholtz Zentrum München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural pH regulatory mechanisms can be overruled during several pathologies such as cancer, inflammation and ischaemia, leading to local pH changes in the human body. Here we demonstrate that

Indexed as

AnimalsCarbon IsotopesContrast MediaFemaleFuransHeLa CellsHumansHydrogen-Ion ConcentrationInjections, SubcutaneousKidneyMagnetic Resonance ImagingMammary Neoplasms, AnimalMCF-7 CellsRatsStaining and LabelingUrinary BladderCarbon-13Carbon IsotopesContrast MediaFurans

Identifiers

PMID28492229
PMCPMC5482723
OpenAlexW2613726711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.