ArticleOpen forum infectious diseases2017
Dengue Virus Entry and Replication Does Not Lead to Productive Infection in Platelets.
Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Platelet-like particles released from Ebola virus-infected megakaryocytic cells behave like virus-like particles.PLoS pathogens · 2026Article
- Potential Mechanisms Underlying Bleeding During Infection With Hemorrhagic Fever Viruses.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Human platelets support Semliki Forest virus replication.BMC research notes · 2025Article
- Dengue virus infection: how platelet-leukocyte crosstalk shapes thrombotic events and inflammation.Molecular biology reports · 2025Review
- Platelets in infection: intrinsic roles and functional outcomes.Frontiers in immunology · 2025Review
- Article
- Neutralizing antibodies from prior exposure to dengue virus negatively correlate with viremia on re-infection.Communications medicine · 2023Article
- Platelet derived exosomes disrupt endothelial cell monolayer integrity and enhance vascular inflammation in dengue patients.Frontiers in immunology · 2023Article
- Platelet proteome reveals features of cell death, antiviral response and viral replication in covid-19.Cell death discovery · 2022Article
- Platelets in Viral Infections - Brave Soldiers or Trojan Horses.Frontiers in immunology · 2022Review
- Dengue induces iNOS expression and nitric oxide synthesis in platelets through IL-1R.Frontiers in immunology · 2022Article
- Dengue virus replication enhances labile zinc pools by modulation of ZIP8.Cellular microbiology · 2021Article
- Oxidative stress specifically inhibits replication of dengue virus.The Journal of general virology · 2021Article
- Dengue Fever: Therapeutic Potential ofFrontiers in pharmacology · 2021Review
- Inflammatory signaling in dengue-infected platelets requires translation and secretion of nonstructural protein 1.Blood advances · 2020Article
- Zinc Chelation Specifically Inhibits Early Stages of Dengue Virus Replication by Activation of NF-κB and Induction of Antiviral Response in Epithelial Cells.Frontiers in immunology · 2019Article
- Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques.Nature communications · 2018Article
- Dengue Virus Induces the Release of sCD40L and Changes in Levels of Membranal CD42b and CD40L Molecules in Human Platelets.Viruses · 2018Article
- Platelets in Immune Response to Virus and Immunopathology of Viral Infections.Frontiers in medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Thrombocytopenia is a characteristic feature during the acute phase of dengue infection and has been found to associate with vascular leakage in severe dengue. Although dengue antigens have been observed in platelets, there is no strong evidence to suggest a direct infection of platelets by dengue virus as a contributing factor for thrombocytopenia. We show that dengue virus can enter platelets but replicate viral ribonucleic acid to a minimal extent and, therefore, cannot produce infectious virus. Dengue antigen was undetectable in platelets isolated from dengue patients; however, we observed an increase in CD14
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.