ArticleEndocrinology, diabetes & metabolism case reports2017
Giant parathyroid adenoma: differential aspects compared to parathyroid carcinoma.
Article in Endocrinology, diabetes & metabolism case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Giant parathyroid tumours in primary hyperparathyroidism: a systematic review.Langenbeck's archives of surgery · 2022Pooled it
- Multimodality imaging localization of a giant functional parathyroid adenoma in a young fitness trainer with delayed recognition of hypercalcemia: A case report.Radiology case reports · 2026Article
- A Giant Parathyroid Adenoma Presenting as Coughs and Dyspnea in a Young Woman: A Case Report.Clinical case reports · 2026Article
- A case report of primary hyperparathyroidism due to a giant substernal parathyroid adenoma managed using a neck incision approach.Medicine · 2025Article
- An exceptionally rare case of a giant parathyroid adenoma with carcinoma-like presentation.Hormones (Athens, Greece) · 2025Article
- Giant parathyroid adenoma causing severe hypercalcemia; a case report from Duhok.Annals of medicine and surgery (2012) · 2023Article
- Surgical challenges of giant parathyroid adenomas weighing 10 g or more.Journal of endocrinological investigation · 2023Article
- Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report.Clinical case reports · 2023Article
- Primary hyperparathyroidism-related giant parathyroid adenoma (Review).Experimental and therapeutic medicine · 2022Review
- Giant Parathyroid Adenoma-Associated Fracture, Not All Lytic Bone Lesions areCase reports in medicine · 2022Article
- Mediastinal ectopic parathyroid adenomas: diagnostic and therapeutic challenge.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2021Article
- Giant parathyroid adenoma and challenges with preoperative differentiation from malignancy.BMJ case reports · 2021Article
- Giant Parathyroid Adenoma versus Parathyroid Carcinoma: Differentiating Two Entities.Journal of the ASEAN Federation of Endocrine Societies · 2021Article
- Severe hypercalcaemia of primary hyperparathyroidism: Could giant adenoma be the real culprit rather than carcinoma?Annals of the Royal College of Surgeons of England · 2020Article
- Giant parathyroid adenoma presenting with a pathological left clavicular fracture: An extremely rare case report.International journal of surgery case reports · 2020Article
- Giant parathyroid adenoma: a case report and review of the literature.Journal of medical case reports · 2019Review
- A Giant Parathyroid Tumor during Pregnancy: Adenoma versus Carcinoma.Case reports in pathology · 2019Article
- A Rare Case of Primary Hyperparathyroidism Caused by a Giant Solitary Parathyroid Adenoma.The American journal of case reports · 2018Review
- A Case of Hyperparathyroidism due to a Large Intrathyroid Parathyroid Adenoma with Recurrent Episodes of Acute Pancreatitis.Case reports in endocrinology · 2017Article
- Hypercalcemic Crisis Caused by a Parathyroid Mass Requiring Thoracoscopic Resection.AACE clinical case reportsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 85% of cases of primary hyperparathyroidism (PHPT) are due to parathyroid adenomas (PA) and less than 1% to parathyroid carcinomas (PC). The PA usually measure <2 cm, weigh <1 g and generate a mild PHPT, whereas the PC usually exceeds these dimensions and are associated with a severe PHPT. However, giant PA (GPA), which is defined as those larger than 3 g, has been documented. Those may be associated with very high levels of PTH and calcium. In these cases, their differentiation before and after surgery with PC is very difficult. We present a case of severe PHPT associated with a large parathyroid lesion, and we discuss the differential aspects between the GPA and PC. LEARNING POINTS: In parathyroid lesions larger than 2 cm, the differential diagnosis between GPA and PC should be considered.Pre and postsurgical differentiation between GPA and PC is difficult; however, there are clinical, analytical and radiographic characteristics that may be useful.The depth/width ratio larger or smaller than 1 seems to be the most discriminatory ultrasound parameter for the differential diagnosis.Loss of staining for parafibromin has a specificity of 99% for the diagnosis of PC.The simultaneous presence of several histological characteristics, according to the classification of Schantz and Castleman, is frequent in PC and rare in GPA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.