Evidence map›Paper›PMID 28491289›Full record

ReviewF1000Research2017

Recent advances in preoperative management of esophageal adenocarcinoma.

Kazuto Harada, Dilsa Mizrak Kaya, Hideo Baba, Jaffer A Ajani

Open access · goldAbstract readReview
In one paragraph

Review in F1000Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kazuto HaradaDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Texas, USA.ORCID 0000-0001-5818-7072
Dilsa Mizrak KayaDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Texas, USA.
Hideo BabaDepartment of Gastroenterological Surgery, Kumamoto University, Jonjo, Kumamoto, Japan.
Jaffer A AjaniDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Texas, USA.
The University of Texas MD Anderson Cancer Center · USKumamoto University Hospital · JP

Funding

Prediction of Pathologic Complete Response by Gene Expression Profiling in EsophaR01CA138671 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AJANI, JAFFER A. · 2010 to 2014
$1.5M
Inhibition of Hedgehog Signaling in Gli-1+Adeno CA of the Esoph or GE junctionR01CA172741 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AJANI, JAFFER A. · 2013 to 2017
$1.4M
NCI NIH HHS R01 CA138671NCI NIH HHS R01 CA172741
6 · The paper itself

Abstract

Esophageal cancer is an aggressive malignancy with increasing incidence, and the prognosis of patients treated by surgery alone remains dismal. Preoperative treatment can modestly prolong overall survival. Preoperative chemotherapy or chemoradiation is the standard of care for resectable esophageal cancer (greater than clinical stage I and less than clinical stage IV). One of the challenges is to predict complete response in the surgical specimen from preoperative therapy and to avoid surgery in some patients but also predict ineffectiveness of preoperative therapy if the tumor is resistant and avoid such therapies altogether. In-depth understanding of the molecular biology could lead to personalized therapy, and in the future, clinical trials designed according to molecular features are expected. Here, we summarize preoperative treatment for esophageal adenocarcinoma and their potential.

Indexed as

Esophageal cancerpersonalized therapypreoperative therapy

Identifiers

PMID28491289
PMCPMC5399958
OpenAlexW2606492667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.