ArticleF1000Research2017
Midlife interventions are critical in prevention, delay, or improvement of Alzheimer's disease and vascular cognitive impairment and dementia.
Article in F1000Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Lifetime Patterns of Earned Income Tax Credit Eligibility and Cognition: A Sequence Analysis Approach.American journal of preventive medicine · 2026Article
- Menopause-related brain fog as a midlife window in women's brain aging: toward ecologically valid measurement and digital phenotyping.Frontiers in human neuroscience · 2026Article
- Intervention on Modifiable Lifestyle and Physiological Factors via Variational Autoencoder Reveals Changes in Functional Connectivity-Mediated Risk for Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2025Article
- Associations of aortic and carotid artery health with cerebrovascular markers and cognition in older adults from the Whitehall II imaging study.BMC medicine · 2025Article
- Linkages between incarceration and health for older adults.Health & justice · 2025Review
- Circulating serum metabolites as predictors of dementia: a machine learning approach in a 21-year follow-up of the Whitehall II cohort study.BMC medicine · 2022Article
- Mid age APOE ε4 carriers show memory-related functional differences and disrupted structure-function relationships in hippocampal regions.Scientific reports · 2020Article
- Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The basic strategy for focusing exclusively on genetically identified targets for intervening in late life dementias was formulated 30 years ago. Three decades and billions of dollars later, all efforts at disease-modifying interventions have failed. Over that same period, evidence has accrued pointing to dementias as late-life clinical phenotypes that begin as midlife pathologies. Effective prevention therefore may need to begin in midlife, in order to succeed. No current interventions are sufficiently safe to justify their use in midlife dementia prevention trials. Observational studies could be informative in testing the proposal that amyloid imaging and
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.