Evidence map›Paper›PMID 28491274›Full record

ArticleJournal of tissue engineering

Biomimetic strategies for fracture repair: Engineering the cell microenvironment for directed tissue formation.

Wollis J Vas, Mittal Shah, Rawiya Al Hosni, Helen C Owen, Scott J Roberts

Abstract read
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wollis J VasDepartment of Materials & Tissue, Institute of Orthopaedics & Musculoskeletal Science, University College London, Stanmore, UK.
Mittal ShahDepartment of Materials & Tissue, Institute of Orthopaedics & Musculoskeletal Science, University College London, Stanmore, UK.
Rawiya Al HosniDepartment of Materials & Tissue, Institute of Orthopaedics & Musculoskeletal Science, University College London, Stanmore, UK.
Helen C OwenDepartment of Natural Sciences, School of Science & Technology, Middlesex University, London, UK.
Scott J RobertsDepartment of Materials & Tissue, Institute of Orthopaedics & Musculoskeletal Science, University College London, Stanmore, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complications resulting from impaired fracture healing have major clinical implications on fracture management strategies. Novel concepts taken from developmental biology have driven research strategies towards the elaboration of regenerative approaches that can truly harness the complex cellular events involved in tissue formation and repair. Advances in polymer technology and a better understanding of naturally derived scaffolds have given rise to novel biomaterials with an increasing ability to recapitulate native tissue environments. This coupled with advances in the understanding of stem cell biology and technology has opened new avenues for regenerative strategies with true clinical translatability. These advances have provided the impetus to develop alternative approaches to enhance the fracture repair process. We provide an update on these advances, with a focus on the development of novel biomimetic approaches for bone regeneration and their translational potential.

Indexed as

biomaterialsbiomimeticendochondral ossificationFracture repairstem cells

Identifiers

PMID28491274
PMCPMC5406151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.