Evidence map›Paper›PMID 28491147›Full record

ReviewTherapeutic advances in medical oncology2017

A clinical guide to the management of genitourinary symptoms in breast cancer survivors on endocrine therapy.

Mariana S Sousa, Michelle Peate, Sherin Jarvis, Martha Hickey, Michael Friedlander

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Therapeutic advances in medical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04515888 (Evaluation of the Prevalence of Pelvic Static Disorders in Women Treated for Localized Breast Cancer During Adjuvant Hormone Therapy.), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04515888 completednot on this mapstarted 2020, after this paper: background citation

Evaluation of the Prevalence of Pelvic Static Disorders in Women Treated for Localized Breast Cancer During Adjuvant Hormone Therapy.

TypeobservationalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2020 to 2021Enrolled246ConditionsBreast CancerArmsPFDI-20 / PFIQ-7 questionnaires
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Impact of fractional COLasers in medical science · 2026
    Trial
  4. Trial
  5. Trial
  6. Trial
  7. The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Trial
  8. Article
  9. Review
  10. Observational
  11. Article
  12. Article
  13. Beyond cancer treatment: dermo-aesthetic and other wellness recommendations for breast cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  14. Review
  15. Article
  16. Vaginal COBMC cancer · 2023
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Mariana S SousaSchool of Nursing and Midwifery, Western Sydney University, Centre for Applied Nursing Research, South Western Sydney Local Health District, Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia Prince of Wales Clinical School, University of New South Wales Australia Sydney, New South Wales, Australia.
Michelle PeateDepartment of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville, Victoria, Australia.
Sherin JarvisPelvic Floor Physiotherapy, Women's Health & Research Institute of Australia, New South Wales, Australia.
Martha HickeyDepartment of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville, Victoria, Australia.
Michael FriedlanderPrince of Wales Clinical School, University of New South Wales Australia, Sydney, New South Wales, Australia Department of Medical Oncology, Prince of Wales Hospital, Randwick, New South Wales, Australia.
Royal Women's Hospital · AUUniversity of Melbourne · AUUNSW Sydney · AUWomen's & Children's Health Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is increasing attention and concern about managing the adverse effects of adjuvant endocrine therapy for women with early breast cancer as the side effects of therapy influence compliance and can impair quality of life (QoL). Most side effects associated with tamoxifen (TAM) and aromatase inhibitors (AIs) are directly related to estrogen deprivation, and the symptoms are similar to those experienced during natural menopause but appear to be more severe than that seen in the general population. Prolonged estrogen deprivation may lead to atrophy of the vulva, vagina, lower urinary tract and supporting pelvic structures, resulting in a range of genitourinary symptoms that can in turn lead to pain, discomfort, impairment of sexual function and negatively impact on multiple domains of QoL. The genitourinary side effects may be prevented, reduced and managed in most cases but this requires early recognition and appropriate treatment. We provide an overview of practical clinical approaches to understanding the pathophysiology and the management of genitourinary symptoms in postmenopausal women receiving adjuvant endocrine therapy for breast cancer.

Indexed as

atrophybreast cancerendocrine therapyestrogengenitourinary symptomsmanagementmenopauseoncology

Identifiers

PMID28491147
PMCPMC5405994
OpenAlexW2585517063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.