Evidence map›Paper›PMID 28491140›Full record

ArticleTherapeutic advances in gastroenterology2017

Tryptase mast cell density, protease-activated receptor-2 microvascular density, and classical microvascular density evaluation in gastric cancer patients undergoing surgery: possible translational relevance.

Michele Ammendola, Rosario Sacco, Giuseppina Vescio, Valeria Zuccalà, Maria Luposella, Rosa Patruno, Nicola Zizzo, Claudia Gadaleta, Ilaria Marech, Roberta Ruggieri and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Therapeutic advances in gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Mast Cells, Angiogenesis and Lymphangiogenesis in Human Gastric Cancer.International journal of molecular sciences · 2019
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Michele AmmendolaDepartment of Medical and Surgical Sciences, Clinical Surgery Unit, University of Catanzaro 'Magna Graecia' Medical School, Viale Europa - Germaneto, 88100, Catanzaro, Italy.
Rosario SaccoDepartment of Medical and Surgical Sciences, Clinical Surgery Unit, University of Catanzaro 'Magna Graecia' Medical School, Catanzaro, Italy.
Giuseppina VescioDepartment of Medical and Surgical Sciences, Clinical Surgery Unit, University of Catanzaro 'Magna Graecia' Medical School, Catanzaro, Italy.
Valeria ZuccalàHealth Science Department, Pathology Unit, University of Catanzaro 'Magna Graecia' Medical School, Catanzaro, Italy.
Maria LuposellaCardiovascular Disease Unit, 'San Giovanni di Dio' Hospital, Crotone, Italy.
Rosa PatrunoChair of Pathology, University 'Aldo Moro' Veterinary Medical School, Bari, Italy.
Nicola ZizzoChair of Pathology, University 'Aldo Moro' Veterinary Medical School, Bari, Italy.
Claudia GadaletaChair of Pathology, University 'Aldo Moro' Veterinary Medical School, Bari, Italy.
Ilaria MarechDiagnostic and Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre, 'Giovanni Paolo II', Bari, Italy.
Roberta RuggieriDiagnostic and Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre, 'Giovanni Paolo II', Bari, Italy.
Ibrahim Furkan KocakDepartment of Biochemistry, Gulhane Military Medical Academy Etlik, Ankara, Turkey.
Taner OzgurtasDepartment of Biochemistry, Gulhane Military Medical Academy Etlik, Ankara, Turkey.
Cosmo Damiano GadaletaDiagnostic and Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre, 'Giovanni Paolo II', Bari, Italy.
Giuseppe SammarcoDepartment of Medical and Surgical Sciences, Clinical Surgery Unit, University of Catanzaro 'Magna Graecia' Medical School, Catanzaro, Italy.
Girolamo RanieriDiagnostic and Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre, 'Giovanni Paolo II', Bari, Italy.
Magna Graecia University · ITUniversity of Bari Aldo Moro · ITIstituto Tumori Bari · ITTurkish Armed Forces · TRNuovo Ospedale San Giovanni di Dio · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular, MCs can release tryptase, a potent

methodsIn this study, we analyzed the correlation of TMCD, PAR-2-MVD, C-MVD with each other and with the main clinicopathological features in GC patients who underwent surgery. A series of 77 GC patients with stage T

resultsTumour tissue samples were evaluated by mean of immunohistochemistry and image analysis methods in terms of numbers of TMCD, PAR-2-MVD and C-MVD. A significant correlation between the TMCD, PAR-2-MVD and C-MVD groups with each other was found by Pearson

conclusionsOur

Indexed as

angiogenesisgastric cancermast cellsPAR-2tryptase

Identifiers

PMID28491140
PMCPMC5405880
OpenAlexW2585061295

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.