Evidence map›Paper›PMID 28491119›Full record

ArticleNutrition & metabolism2017

Association of adipokines with blood pressure, arterial elasticity and cardiac markers in dialysis patients: cross-sectional analysis of baseline data from a cohort study.

Wenjin Liu, Lei Jiang, Jianping Chen, Chaoqing Gao, Jianmei Zhou, Jiajun Zhou, Youwei Bai, Hong Chu, Wei Fan, Liang Wang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nutrition & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Relationship between circulating leptin levels and arterial stiffness: a systematic review and meta-analysis of observational studies.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Wenjin LiuCenter for Kidney Disease, Second Affiliated Hospital of Nanjing Medical University, 262# North Zhongshan Road, Nanjing, 210003 China.
Lei JiangCenter for Kidney Disease, Second Affiliated Hospital of Nanjing Medical University, 262# North Zhongshan Road, Nanjing, 210003 China.
Jianping ChenDepartment of Statistics Analysis, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Chaoqing GaoDepartment of Hemodialysis, Yijishan Hospital of Wannan Medical College, Wuhu, China.
Jianmei ZhouDepartment of Hemodialysis, Yijishan Hospital of Wannan Medical College, Wuhu, China.
Jiajun ZhouDepartment of Hemodialysis, Yijishan Hospital of Wannan Medical College, Wuhu, China.
Youwei BaiDepartment of Nephrology, Luan People's Hospital, Luan, China.
Hong ChuDepartment of Nephrology, Affiliated Yixing People's Hospital, Jiangsu University, Yixing, China.
Wei FanDepartment of Nephrology, Affiliated Yixing People's Hospital, Jiangsu University, Yixing, China.
Liang WangDepartment of Nephrology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
Zhuxing SunDepartment of Nephrology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
Xiurong LiDepartment of Blood Purification, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Junwei YangCenter for Kidney Disease, Second Affiliated Hospital of Nanjing Medical University, 262# North Zhongshan Road, Nanjing, 210003 China.
Second Affiliated Hospital of Nanjing Medical University · CNWannan Medical College · CNWuxi People's Hospital · CNFirst Affiliated Hospital of Wannan Medical College · CNJiangsu University · CNLu'an First People's Hospital · CNNanjing Drum Tower Hospital · CNSoochow University · CNYixing People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdipokines are a set of cytokines secreted by white adipose tissue that have been suggested to be involved in the development of cardiovascular diseases. We aimed to evaluate the cross-sectional associations of a panel of representative adipokines with cardiovascular measures in a cohort of hemodialysis patients.

methodsWe measured plasma adiponectin, resistin, plasminogen activator inhibitor-1 (PAI-1), leptin, monocyte chemotactic protein 1 (MCP-1) and adipsin levels in 366 dialysis patients and 60 healthy controls. The associations of these adipokines with systolic blood pressure (assessed by ambulatory blood pressure monitoring), pulse wave velocity (PWV) and cardiac markers (BNP, NT-proBNP, Troponin I, Troponin T) in these patients were determined by general linear models with stepwise adjustment for covariates.

resultsIn unadjusted comparison with controls, dialysis patients showed increased adiponectin, resistin, MCP-1 and adipsin levels, decreased PAI-1 concentrations (all

conclusionsWe found significant associations between adipokines and cardiovascular measures. Our data suggest the possible involvement of adipokines in cardiovascular modulation in dialysis patients.

Indexed as

AdipokinesArterial elasticityBlood pressureCardiovascular diseaseDialysis

Identifiers

PMID28491119
PMCPMC5424399
OpenAlexW2613017899

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.