Evidence map›Paper›PMID 28490893›Full record

ReviewJournal of asthma and allergy2017

Sesame allergy: current perspectives.

Adil Adatia, Ann Elaine Clarke, Yarden Yanishevsky, Moshe Ben-Shoshan

4 registry-linked trialsAbstract readReview
In one paragraph

Review in Journal of asthma and allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05158413 naunknown statusnot on this mapstarted 2022, after this paper: background citation

High and Low Dose Oral Sesame Immunotherapy - Comparison of Efficacy and Safety

TypeinterventionalSponsorMedical University of WarsawRan2022 to 2025Enrolled40ConditionsFood AllergyArmsHigh dose, Low dose
NCT05923216 naenrolling by invitationnot on this mapstarted 2023, after this paper: background citation

Induction of Sustained Unresponsiveness to Sesame Using High- and Low-dose Sesame Oral Immunotherapy - Evaluation of Efficacy and Safety

TypeinterventionalSponsorMedical University of WarsawRan2023 to 2026Enrolled40ConditionsFood AllergyArmsHigh dose OIT, Low dose OIT
NCT06261554 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy and Safety of Low-dose Sesame Oral Immunotherapy in Pediatric Patients: A Randomized Controlled Trial

TypeinterventionalSponsorMedical University of WarsawRan2024 to 2027Enrolled39ConditionsFood AllergyArmsDietary Supplement: Low dose OIT
NCT07107451 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of the Acquisition of Sustained Unresponsiveness (SU) to Sesame Protein Following Low-dose Oral Immunotherapy - Long-term Follow-up of Patients From the RCT Efficacy and Safety of Low-dose Sesame Oral Immunotherapy in Pediatric Patients, NCT06261554.

TypeinterventionalSponsorMedical University of WarsawRan2025 to 2029Enrolled39ConditionsFood Allergy in ChildrenArmsOIT with low dose sesame protein
3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Latin American anaphylaxis registry.The World Allergy Organization journal · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Autoinjector - A smart device for emergency cum personal therapy.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021
    Review
  13. Recent advances in the management of nut allergy.The World Allergy Organization journal · 2021
    Review
  14. Food Allergy: Searching for the Modern Environmental Culprit.The Yale journal of biology and medicine · 2020
    Review
  15. Article
  16. Component-Resolved Diagnosis in Food Allergies.Medicina (Kaunas, Lithuania) · 2019
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adil AdatiaDepartment of Medicine, University of Alberta, Edmonton.
Ann Elaine ClarkeDivision of Rheumatology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary.
Yarden YanishevskySection of Allergy and Clinical Immunology, Department of Pediatrics, University of Alberta, Edmonton, AB.
Moshe Ben-ShoshanDivision of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sesame is an important global allergen affecting ~0.1% of the North American population. It is a major cause of anaphylaxis in the Middle East and is the third most common food allergen in Israel. We conducted a systematic review of original articles published in the last 10 years regarding the diagnosis and management of sesame allergy. Skin prick testing appears to be a useful predictor of sesame allergy in infants, although data are less consistent in older children and adults. The diagnostic capacity of serum-specific immunoglobulin E is poor, especially in studies that used oral food challenges to confirm the diagnosis. Double-blind, placebo-controlled food challenge thus remains the diagnostic gold standard for sesame allergy. The cornerstone of sesame allergy management is allergen avoidance, though accidental exposures are common and patients must be prepared to treat the consequent reactions with epinephrine. Novel diagnostic and treatment options such as component-resolved diagnostics, basophil activation testing, and oral immunotherapy are under development but are not ready for mainstream clinical application.

Indexed as

component-resolved diagnosticsepinephrine autoinjectorsesame allergyskin prick testingspecific IgE

Identifiers

PMID28490893
PMCPMC5414576

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.