ArticleInternational journal of chronic obstructive pulmonary disease2017
Correlation between fractional exhaled nitric oxide and sputum eosinophilia in exacerbations of COPD.
Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Association Between Fractional Exhaled Nitric Oxide (FeNO) and Cognitive Function in Patients with Obstructive Sleep Apnea.Nature and science of sleep · 2025Article
- Temporal Dynamics of Fractional Exhaled Nitric Oxide (FeNO) During CPAP Therapy in Obstructive Sleep Apnea: A Prospective Follow-Up Study.Nature and science of sleep · 2025Article
- Correlation of sputum inflammatory markers with severity and blood inflammatory markers in bronchiectasis.Journal of thoracic disease · 2024Article
- Phenotypes, Etiotypes, and Endotypes of Exacerbations of Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2023Review
- Blood eosinophils in chronic obstructive pulmonary disease: A potential biomarker.Journal of translational internal medicine · 2023Article
- Blood Eosinophils and Exhaled Nitric Oxide: Surrogate Biomarkers of Airway Eosinophilia in Stable COPD and Exacerbation.Biomedicines · 2022Review
- Induced sputum metabolomic profiles and oxidative stress are associated with chronic obstructive pulmonary disease (COPD) severity: potential use for predictive, preventive, and personalized medicine.The EPMA journal · 2020Article
- The Role of Electronic Noses in Phenotyping Patients with Chronic Obstructive Pulmonary Disease.Biosensors · 2020Review
- Clinical Features of Chronic Obstructive Pulmonary Disease with High Fractional Exhaled Nitric Oxide.Tuberculosis and respiratory diseases · 2020Article
- Relationship of Blood Eosinophils with Fractional Exhaled Nitric Oxide and Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease (COPD) Exacerbation.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Blood cell for the differentiation of airway inflammatory phenotypes in COPD exacerbations.BMC pulmonary medicine · 2020Article
- Predictive Value of Exhaled Nitric Oxide and Blood Eosinophil Count in the Assessment of Airway Eosinophilia in COPD.International journal of chronic obstructive pulmonary disease · 2020Article
- Role of the Bronchodilator Test Defined by the Forced Vital Capacity in Chronic Obstructive Pulmonary Disease Phenotyping.International journal of chronic obstructive pulmonary disease · 2020Article
- Relationship between Particulate Matter (PMCanadian respiratory journal · 2020Article
- The Value of FENO Measurement for Predicting Treatment Response in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2020Article
- Clinical utility of exhaled nitric oxide fraction in the management of asthma and COPD.Breathe (Sheffield, England) · 2019Review
- Association Between Blood Eosinophils and Mortality in Critically Ill Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.International journal of chronic obstructive pulmonary diseaseArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMeasurements of eosinophils in induced sputum and fractional exhaled nitric oxide (FeNO) are noninvasive biomarkers for assessing airway inflammation phenotypes in chronic obstructive pulmonary disease (COPD). Nevertheless, the clinical application of the correlation between FeNO levels and sputum eosinophilia is controversial. The study aimed to investigate the correlation and predictive relationship between FeNO levels and sputum eosinophils in patients with COPD exacerbation. It also examined the relationship between FeNO levels and blood eosinophil percentage.
methodsA total of 163 patients with COPD exacerbation were included in the cross-sectional study. All patients underwent the following on the same day: FeNO test, spirometry, bronchodilator reversibility test, induced sputum, and routine blood test. They were classified as eosinophilic group or noneosinophilic group based on sputum eosinophilic percentage (≥2.5%)/FeNO levels (≥32 parts per billion [ppb]).
resultsFeNO levels and blood eosinophilic percentage were higher in patients with sputum eosinophilia (n=62) compared to those without (31.35 ppb versus 21.43 ppb,
conclusionThe clinical relevance of this study provides evidence that inflammatory biomarkers, including sputum eosinophilic percentage, FeNO level, and blood eosinophilic percentage, can be used to positively diagnose eosinophilic COPD. The FeNO level and blood eosinophilic counts/percentage, which determine an optimal cutoff for sputum eosinophilia, need more studies.
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