ReviewClinical interventions in aging2017
Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: a systematic overview - the SENATOR Project ONTOP Series.
Review in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05790863 (Effects of Low-volume High-intensity Training Versus Moderate-intensity Continuous Training on Physical Performance in Older Adults With Possible Sarcopenia), which is not on this map. Cited by 65 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Low-volume High-intensity Training Versus Moderate-intensity Continuous Training on Physical Performance in Older Adults With Possible Sarcopenia
Who cites it
65 citing papers in PubMed, 6 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Exercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review.The journal of nutrition, health & aging · 2026Pooled it
- Exercise for frailty research frontiers: a bibliometric analysis and systematic review.Frontiers in medicine · 2024Pooled it
- Pooled it
- Pooled it
- Physical Activity, Injurious Falls, and Physical Function in Aging: An Umbrella Review.Medicine and science in sports and exercise · 2019Pooled it
- Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management.The journal of nutrition, health & aging · 2019Guideline
- Functional Activities to Optimize Patient Outcomes in Home Health: A Pilot Randomized Controlled Trial.Journal of the American Medical Directors Association · 2026Trial
- Healthcare Professionals' Perspectives on the Impact of a Multicomponent Intervention for Older People With Frailty Discharged From Hospital-A Theory-Based Evaluation.Journal of evaluation in clinical practice · 2025Trial
- Trial
- Nordic walking with an integrated resistance shock absorber affects the femur strength and muscles torques in postmenopausal women.Scientific reports · 2022Trial
- A Nutritionally Complete Oral Nutritional Supplement Powder Improved Nutritional Outcomes in Free-Living Adults at Risk of Malnutrition: A Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Trial
- Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- Article
- Sarcopenia: current state of knowledge and its implications in orthopaedics and traumatology for enhanced clinical strategies and patient outcomes.Musculoskeletal surgery · 2026Review
- Impacts of exercise, renin-angiotensin system modulation or both on skeletal muscle circadian gene expression.Experimental physiology · 2026Article
- Frailty among adult people living with HIV in Tanzania: a single-centred hospital-based cross-sectional study.BMJ public health · 2026Article
- Frailty Index Predicts Future All-cause Mortality and Quality of Life: A 2-Year Follow-up Study Among Korean Older Adults From a Population-based Cohort Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Sarcopenia as a predictor of mortality in centenarians: insights from a prospective cohort study.BMC geriatrics · 2025Article
- Prognostic significance of preoperative CT-based sarcopenia in locally advanced rectal cancer: a multicenter retrospective study.BMC cancer · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death. Some systematic reviews (SRs) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them.
objectiveTo critically appraise the evidence from SRs of the primary studies on nonpharmacological interventions to treat PF (defined by Fried's frailty phenotype) and sarcopenia (defined by the EWGSOP) in older patients.
designOverview of SRs and meta-analysis of comparative studies. DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, EMBASE, and CINAHL were searched in October 2015. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: SRs that included at least one comparative study evaluating any nonpharmacological intervention to treat PF or sarcopenia in older patients in any health care setting. Any primary study described in these SRs with experimental design was included. DATA EXTRACTION AND MANAGEMENT: Two reviewers independently screened titles, abstracts, and full-texts of articles. Quality assessment was carried out by using criteria from the Cochrane Collaboration and the GRADE working group.
resultsTen SRs with 5 primary studies satisfied the inclusion criteria. The most frequent interventions in the included studies were physical exercise (4) and nutritional supplementation (2). Muscle strength (MS; except for one study in a frail population) and physical performance (PP; except for another study in a frail population) improved with exercise and amino acid supplementation in frail and sarcopenic old adults. Falls and activities of daily living were assessed in two studies with opposite results. The overall quality of the evidence was low.
conclusionThis overview of SRs highlights the importance of exercise interventions with or without nutritional supplementation to improve the PP in community-dwelling patients aged >65 years with PF and sarcopenia. MS improved with multidisciplinary treatment and exercise interventions in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.