ArticleScientific reports2017
Progranulin deficiency causes the retinal ganglion cell loss during development.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The landscape of plasma proteomic links to human organ imaging.Nature communications · 2026Article
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- The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol.Frontiers in immunology · 2024Article
- Temporal single-cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury.Nature immunology · 2023Article
- Retinal Degeneration and Microglial Dynamics in Mature Progranulin-Deficient Mice.International journal of molecular sciences · 2021Article
- Evidence for ceramide induced cytotoxicity in retinal ganglion cells.Experimental eye research · 2021Article
- Progranulin deficiency in Iba-1Journal of neuroinflammation · 2021Article
- Factors Associated with Changes in Retinal Layers Following Acute Optic Neuritis: A Longitudinal Study Using Optical Coherence Tomography.Journal of clinical medicine · 2020Article
- Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease?Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Potential effects of progranulin and granulins against retinal photoreceptor cell degeneration.Molecular vision · 2019Article
- Granulin 1 Promotes Retinal Regeneration in Zebrafish.Investigative ophthalmology & visual science · 2018Article
- VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush.Scientific reports · 2018Article
- Protein phosphatase 2A regulates the p38 signaling pathway to affect the migration of astrocytes.Molecular medicine reports · 2018Article
- Microglia increases the proliferation of retinal precursor cells during postnatal development.Molecular vision · 2018Article
- Progranulin Insufficiency Affects Lysosomal Homeostasis in Retinal Pigment Epithelium.In vivo (Athens, Greece)Article
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Authors and funding
5 authors.
Funding
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Abstract
Astrocytes are glial cells that support and protect neurons in the central nervous systems including the retina. Retinal ganglion cells (RGCs) are in contact with the astrocytes and our earlier findings showed the reduction of the number of cells in the ganglion cell layer in adult progranulin deficient mice. In the present study, we focused on the time of activation of the astrocytes and the alterations in the number of RGCs in the retina and optic nerve in progranulin deficient mice. Our findings showed that the number of Brn3a-positive cells was reduced and the expression of glial fibrillary acidic protein (GFAP) was increased in progranulin deficient mice. The progranulin deficient mice had a high expression of GFAP on postnatal day 9 (P9) but not on postnatal day 1. These mice also had a decrease in the number of the Brn3a-positive cells on P9. Taken together, these findings indicate that the absence of progranulin can affect the survival of RGCs subsequent the activation of astrocytes during retinal development.
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