Evidence map›Paper›PMID 28490635›Full record

ArticleThe Journal of biological chemistry2017

The FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm,

Baosheng Zeng, Yuping Huang, Jun Xu, Takahiro Shiotsuki, Hua Bai, Subba Reddy Palli, Yongping Huang, Anjiang Tan

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Insects · 2026
    Article
  3. Review
  4. The Role of theLife (Basel, Switzerland) · 2025
    Article
  5. Expression ofLife (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Transcription FactorInternational journal of molecular sciences · 2024
    Article
  13. Overexpression ofInternational journal of molecular sciences · 2023
    Article
  14. Article
  15. Frontiers in physiology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. CRISPR/Cas9-mediatedFrontiers in physiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Baosheng ZengKey Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yuping HuangKey Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Jun XuKey Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Takahiro ShiotsukiNational Agriculture and Food Research Organization, Institute of Agrobiological Sciences, Division of Insect Science, 1-2 Owashi, Tsukuba, Ibaraki 305-8634, Japan.
Hua BaiDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, Iowa 50011.
Subba Reddy PalliDepartment of Entomology, University of Kentucky, Lexington, Kentucky 40546-0091.
Yongping HuangKey Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Anjiang TanKey Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address: ajtan01@sibs.ac.cn.
Chinese Academy of Sciences · CNIowa State University · USNational Agriculture and Food Research Organization · JPUniversity of Kentucky · US

Funding

Molecular Analysis of Juvenile Hormone ActionR01GM070559 · NIGMS · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2005 to 2024
$4.1M
NIGMS NIH HHS R01 GM070559
6 · The paper itself

Abstract

Forkhead box O (FOXO) functions as the terminal transcription factor of the insulin signaling pathway and regulates multiple physiological processes in many organisms, including lifespan in insects. However, how FOXO interacts with hormone signaling to modulate insect growth and development is largely unknown. Here, using the transgene-based CRISPR/Cas9 system, we generated and characterized mutants of the silkworm

Indexed as

Metamorphosis, BiologicalAnimalsAnimals, Genetically ModifiedBombyxCarboxylic Ester HydrolasesCRISPR-Cas SystemsEcdysteroneEnzyme InductionEpoxide HydrolasesFemaleForkhead Box Protein O1Gene Expression Regulation, DevelopmentalHydrolysisInsect ProteinsJuvenile HormonesMaleCarboxylic Ester HydrolasesEcdysteroneEpoxide HydrolasesForkhead Box Protein O1Insect Proteinsjuvenile hormone diol kinasejuvenile hormone epoxide hydrolasejuvenile hormone esteraseJuvenile HormonesMethoprenePhosphotransferases (Alcohol Group Acceptor)Bombyx moriCRISPR/Cas9developmentFOXOinsulinJHEjuvenile hormone (JH)

Identifiers

PMID28490635
PMCPMC5512063
OpenAlexW2612644689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.