SynthesisDiabetes2017
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 4 pooled it
14.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.Human genetics · 2023Pooled it
- Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.Communications biology · 2022Pooled it
- Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.The Journal of clinical endocrinology and metabolism · 2021Pooled it
- Genetic Studies of Gestational Diabetes and Glucose Metabolism in Pregnancy.Current diabetes reports · 2020Pooled it
- Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With MTNR1B Diabetes Risk Variant.Diabetes care · 2026Trial
- MTNR1B genotype and effects of carbohydrate quantity and dietary glycaemic index on glycaemic response to an oral glucose load: the OmniCarb trial.Diabetologia · 2024Trial
- Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases.Nature reviews. Endocrinology · 2026Review
- Polygenic background contributes to GCK-MODY clinical presentation and glycaemic variability.Diabetologia · 2026Article
- Common genetic variants modify disease risk and clinical presentation in monogenic diabetes.Nature metabolism · 2025Article
- Multi-Omics Analysis Revealed the rSNPs Potentially Involved in T2DM Pathogenic Mechanism and Metformin Response.International journal of molecular sciences · 2024Article
- Risk prediction and interaction analysis using polygenic risk score of type 2 diabetes in a Korean population.Scientific reports · 2024Article
- TheFrontiers in endocrinology · 2024Article
- β-Cell Heterogeneity and Plasticity.Advances in anatomy, embryology, and cell biology · 2024Review
- The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story.Annals of medicine · 2023Review
- The influence of insulin-related genetic variants on fetal growth, fetal blood flow, and placental weight in a prospective pregnancy cohort.Scientific reports · 2023Article
- Article
- Genetic associations vary across the spectrum of fasting serum insulin: results from the European IDEFICS/I.Family children's cohort.Diabetologia · 2023Article
- Polygenic scores of diabetes-related traits in subgroups of type 2 diabetes in India: a cohort study.The Lancet regional health. Southeast Asia · 2023Article
- Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes.Research square · 2023Article
- Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.Diabetologia · 2023Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
52 authors at 20 institutions in 11 countries.
Andrew R WoodGenetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, U.K.
Anna JonssonNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI.
Nan WangDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Nienke van LeewenDepartment of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC.
Sayuko KobesPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ.
Joris DeelenMax Planck Institute for Biology of Ageing, Cologne, Germany.
Lorena Boquete-VilarinoGenetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, U.K.
Jussi PaananenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Alena StančákováInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-1375-0252
Dorret I BoomsmaDepartment of Biological Psychology, VU University, Amsterdam, the Netherlands.
Eco J C de GeusDepartment of Biological Psychology, VU University, Amsterdam, the Netherlands.
Elisabeth M W EekhoffDiabetes Center, Internal Medicine Unit, VU University Medical Center, Amsterdam, the Netherlands.
Andreas FritscheDivision of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine IV, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-4987-1961
Mark KramerDiabetes Center, Internal Medicine Unit, VU University Medical Center, Amsterdam, the Netherlands.
Giel NijpelsEMGO+ Institute for Health and Care Research, VU University Medical Center, Department of General Practice, Amsterdam, the Netherlands.
Annemarie Simonis-BikDiabetes Center, Internal Medicine Unit, VU University Medical Center, Amsterdam, the Netherlands.
Timon W van HaeftenDepartment of Internal Medicine, Utrecht University Medical Center, Utrecht, the Netherlands.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI.
Richard N BergmanDiabetes & Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0003-1539-4471
Jaakko TuomilehtoDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC.ORCID 0000-0001-6721-153X
Karina BanasikNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Christopher J GrovesOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, U.K.
Mark I McCarthyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.
Diabetes Research on Patient Stratification (DIRECT)
Ewan R PearsonSchool of Medicine, University of Dundee, Dundee, U.K.
Andrea NataliDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Andrea MariInstitute of Neuroscience, National Research Council, Padova, Italy.
Thomas A BuchananDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.
Anny H XiangDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Anette P GjesingNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hans EibergDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Yii-Derr ChenInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO.
Ulf SmithLundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lynne E WagenknechtWake Forest School of Medicine, Winston-Salem, NC.
Leslie BaierPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu.
Mark WalkerInstitute of Cellular Medicine, Newcastle University, Newcastle, U.K. t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu.
Richard M WatanabeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu.
Leen M 't HartDepartment of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu.
Robert L HansonPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu.
Timothy M FraylingGenetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, U.K. t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu.ORCID 0000-0001-8362-2603
University of Copenhagen · DKNational Institutes of Health · USAmsterdam UMC Location Vrije Universiteit Amsterdam · NLRoyal Devon and Exeter Hospital · GBUniversity of Eastern Finland · FIUniversity of Southern California · USWake Forest University · USCentre for Human Genetics · GBLeiden University Medical Center · NLUniversity of Michigan · USAmsterdam Public Health · NLCedars-Sinai Medical Center · USColorado School of Public Health · USDeutsches Diabetes-Zentrum e.V. · DEKaiser Permanente · USMax Planck Institute for Biology of Ageing · DENational Research Council · ITNewcastle University · GBThe Lundquist Institute · USUniversität für Weiterbildung Krems · AT
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3MStructural Analysis Of Candidate Genes For Type 2 Diabetes and ObesityZIADK069071 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BAIER, LESLIE J · 2009 to 2025
$15.4MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MGenetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2MGenetic Epidemiology of Diabetes and ObesityZIADK069028 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HANSON, ROBERT · 2009 to 2025
$7.5MGenetic & Epidemiologic Predictors of Glucose Homeostasis Measures in HispanicsR01DK085175 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E, WATANABE, RICHARD M · 2010 to 2013
$6.9MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MGENETIC ANALYSIS OF TYPE II DIABETES IN FINNISH POPULATIONZ01HG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 1995 to 2008
$6.2MEuropean Research Council 230374Intramural NIH HHS Z01 HG000024NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NHGRI NIH HHS N01 HG065403NHGRI NIH HHS R01 HG007112NHLBI NIH HHS R01 HL060919NHLBI NIH HHS R01 HL060944NHLBI NIH HHS R01 HL061019NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK085175NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370
Abstract
Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. Here we performed the largest genome-wide association study of first-phase insulin secretion, as measured by intravenous glucose tolerance tests, using up to 5,567 individuals without diabetes from 10 studies. We aimed to refine the mechanisms of 178 known associations between common variants and glycemic traits and identify new loci. Thirty type 2 diabetes or fasting glucose-raising alleles were associated with a measure of first-phase insulin secretion at
Indexed as
AllelesBlood GlucoseC-PeptideDiabetes Mellitus, Type 2Genetic VariationGenome-Wide Association StudyGenotypeGenotyping TechniquesGlucose Tolerance TestHumansInsulinInsulin-Secreting CellsInsulin SecretionLinear ModelsLiverTranscription Factor 7-Like 2 ProteinBlood GlucoseC-PeptideInsulinTCF7L2 protein, humanTranscription Factor 7-Like 2 Protein
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