Evidence map›Paper›PMID 28490592›Full record

ArticleJournal of virology2017

Epstein-Barr Virus Rta-Mediated Accumulation of DNA Methylation Interferes with CTCF Binding in both Host and Viral Genomes.

Yen-Ju Chen, Yu-Lian Chen, Yao Chang, Chung-Chun Wu, Ying-Chieh Ko, Sai Wah Tsao, Jen-Yang Chen, Su-Fang Lin

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Chromatin Control of EBV Infection and Latency.Current topics in microbiology and immunology · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yen-Ju ChenNational Institute of Cancer Research, National Health Research Institutes, Miaoli County, Taiwan.
Yu-Lian ChenNational Institute of Cancer Research, National Health Research Institutes, Miaoli County, Taiwan.
Yao ChangNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan.
Chung-Chun WuNational Institute of Cancer Research, National Health Research Institutes, Miaoli County, Taiwan.
Ying-Chieh KoNational Institute of Cancer Research, National Health Research Institutes, Miaoli County, Taiwan.
Sai Wah TsaoDepartment of Anatomy, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Jen-Yang ChenNational Institute of Cancer Research, National Health Research Institutes, Miaoli County, Taiwan cjy@nhri.org.tw sflin1@gmail.com.
Su-Fang LinNational Institute of Cancer Research, National Health Research Institutes, Miaoli County, Taiwan cjy@nhri.org.tw sflin1@gmail.com.ORCID http://orcid.org/0000-0001-8706-2439
National Health Research Institutes · TWChinese University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rta, an Epstein-Barr virus (EBV) immediate-early protein, reactivates viral lytic replication that is closely associated with tumorigenesis. In previous studies, we demonstrated that in epithelial cells Rta efficiently induced cellular senescence, which is an irreversible G

Indexed as

DNA MethylationGene Expression RegulationVirus ActivationCCCTC-Binding FactorDown-RegulationHerpesvirus 4, HumanHost-Pathogen InteractionsImmediate-Early ProteinsRepressor ProteinsTrans-ActivatorsTranscription, GeneticBRLF1 protein, Human herpesvirus 4CCCTC-Binding FactorCTCF protein, humanImmediate-Early ProteinsRepressor ProteinsTrans-Activatorscell cycle arrestCTCFDNA methylationEpstein-Barr virusgenome topologyimmediate-early protein Rtalytic cycle reactivation

Identifiers

PMID28490592
PMCPMC5512236
OpenAlexW2613387474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.