Trial reportSexually transmitted infections2018
Patterns of prevalent HPV and STI co-infections and associated factors among HIV-negative young Western Cape, South African women: the EVRI trial.
Trial report in Sexually transmitted infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01489527 (Preparedness Study), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preparedness Study: Efficacy of HPV Vaccine to Reduce HIV Infection
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Human papillomavirus (HPV) vaccination for the prevention of cervical cancer and other HPV-related diseases: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Meta-synthesis and science mapping analysis of HIV/HPV co-infection: a global perspective with emphasis on Africa.Globalization and health · 2022Pooled it
- Synergism on Cancer Development of Human Papillomavirus and Chlamydia Trachomatis Co-Infection.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Sociodemographics, behaviour and knowledge of first South African HPV-vaccine recipients.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024Article
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- Estimates of the incidence, prevalence, and factors associated with common sexually transmitted infections among Lebanese women.PloS one · 2024Article
- Prevalence of sexually transmitted infections (STIs), associations with sociodemographic and behavioural factors, and assessment of the syndromic management of vaginal discharge in women with urogenital complaints in Mozambique.Frontiers in reproductive health · 2024Article
- Influence of sexually transmitted infections on the cervical cytological abnormalities among Iranian women: A cross-sectional study.International journal of reproductive biomedicine · 2023Article
- Prevalence of coinfections in a cross-sectional cohort of women screened for multiple pathogens in Peru.Heliyon · 2023Article
- Risk factors and communities disproportionately affected by cervical cancer in the Russian Federation: A national population-based study.The Lancet regional health. Europe · 2022Article
- Molecular Identification of Cervical Microbes in HIV-Negative and HIV-Positive Women in an African Setting Using a Customized Bacterial Vaginosis Microbial DNA Quantitative PCR (qPCR) Array.Microbiology spectrum · 2022Article
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- Patterns of Sexually Transmitted Co-infections and Associated Factors Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China.Frontiers in public health · 2022Article
- Mapping evidence on predictors of adverse sexual and reproductive health outcomes among young women in South Africa: A scoping review.African journal of primary health care & family medicine · 2021Article
- HSV-2 Infection Enhances Zika Virus Infection of Primary Genital Epithelial Cells Independently of the Known Zika Virus Receptor AXL.Frontiers in microbiology · 2021Article
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- Sociodemographic factors and STIs associated withInternational journal of STD & AIDS · 2020Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
objectiveTo estimate the prevalence and describe the patterns of concurrent human papillomavirus (HPV) and STIs and associated factors among HIV-negative young Western Cape, South African women participating in the Efficacy of HPV Vaccine to Reduce HIV Infection (EVRI) trial.
methodsHIV-negative women aged 16-24 years old were enrolled in the EVRI trial (NCT01489527) and randomised to receive the licensed four-valent HPV vaccine or placebo. At study entry, participants were clinically evaluated for five STIs: herpes simplex virus type 2 (HSV-2), chlamydia, gonorrhoea, syphilis and disease-causing HPV genotypes (6/11/16/18/31/33/35/39/45/51/52/56/58/59/68). Demographic and sexual history characteristics were compared among women with STI co-infections, single infection and no infection using Pearson χ
resultsAmong 388 young women, STI co-infection prevalence was high: 47% had ≥2 concurrent STIs, 36% had a single STI and 17% had none of the five evaluated STIs. HPV/HSV-2 (26%) was the most prevalent co-infection detected followed by HPV/HSV-2/
conclusionsAmong high-risk young women from underserved communities such as in Southern Africa, a multicomponent prevention strategy that integrates medical and behavioural interventions targeting both men and women is essential to prevent acquisition of concurrent STI infections and consequent disease. TRIAL REGISTRATION NUMBER: NCT01489527; Post-results.
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