ArticleBMJ open2017
Association between serum osmolarity and mortality in patients who are critically ill: a retrospective cohort study.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 53 citations in OpenAlex.
- The Effect of Acute Psychotic Period on Physiological Values Measured in Blood in Male Patients With Schizophrenia.Alpha psychiatry · 2026Article
- The U-shaped association between serum osmolality and 28-day mortality in patients with acute respiratory failure: a retrospective cohort study using the MIMIC-IV database.Journal of thoracic disease · 2026Article
- Calculated serum osmolarity distribution in critically ill patients with acute pancreatitis: a retrospective cohort study.BMC gastroenterology · 2026Article
- Prevalence of low-intake dehydration in hospitalised older adults: systematic review and meta-analysis.BMJ public health · 2026Article
- Elevated serum osmolarity is associated with 28-day all-cause mortality in patients with cardiac arrest.World journal of emergency medicine · 2026Article
- Serum osmolarity as a predictor of mortality in ICU COVID-19 patients: a retrospective analysis.PeerJ · 2026Article
- Association between serum osmolality trajectories and mortality in sepsis patients: a retrospective multi-cohort study.European journal of medical research · 2025Article
- Associations of weight-derived markers with mortality in patients with Corona virus disease 2019: evidence from hospitals and patients.BMC pulmonary medicine · 2025Article
- Trajectory of serum osmolality changes and 28-day mortality risk in patients with sepsis-associated delirium based on the MIMIC-IV database.Scientific reports · 2025Article
- Association of serum osmolality levels with all-cause mortality risk in patients with DKA.Scientific reports · 2025Observational
- Factors associated with hypertonic dehydration in older Japanese outpatients.Journal of general and family medicine · 2025Article
- Development and validation of a predictive model for hospital mortality in patients with community-acquired pneumonia admitted to the intensive care unit.The Journal of international medical research · 2025Article
- Association Between the Highest Lactate Level on the First Postoperative Day and Postoperative Delirium in Cardiac Surgery Patients.CNS neuroscience & therapeutics · 2025Article
- The U-shaped relationship between serum osmolality and in-hospital mortality in patients with traumatic brain injury: a retrospective study based on the MIMIC-IV database.European journal of medical research · 2025Article
- Analysis of the correlation between the group-based trajectory modeling of serum osmolality and prognosis in patients with sepsis-associated encephalopathy at 72 h after admission.BMC infectious diseases · 2025Article
- Association between osmolality trajectories and mortality in patients with sepsis: a group-based trajectory model in large ICU open access databases.Frontiers in medicine · 2025Article
- The J-shaped relationship between serum osmolality and all-cause mortality in critically ill patients with myocardial infarction: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Association between SARS-CoV-2 viral load and serum biomarkers with mortality in Mexican patients.Journal of education and health promotion · 2025Article
- The U-shaped association between serum osmolality and 28-day mortality in patients with sepsis: a retrospective cohort study.Infection · 2024Article
- The Relationship between the Ratio of Urine Osmolality to Serum Osmolality and Neurological Outcomes in Out-of-hospital Cardiac Arrest Patients.Reviews in cardiovascular medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis research aims to explore the association between serum osmolarity and mortality in patients who are critically ill with specific categories of disease.
designA retrospective cohort study. SETTING AND
participantsData were extracted from an online database named 'Multiparameter Intelligent Monitoring in Intensive Care II'. 16 598 patients were included.
methodsPatients were divided into six disease subgroups based on the diagnosis at admission: cardiac, cerebral, vascular, gastrointestinal, respiratory and non-respiratory. The association between maximum osmolarity (osmolarity
resultsAnalysis of the 16 598 patients revealed a 'U'-shaped relationship between osmolarity and mortality with a threshold of 300 mmoL/L. For patients with non-respiratory disease, both hypo-osmolarity and hyperosmolarity
conclusionsHyperosmolarity is associated with increased mortality in patients who are critically ill with cardiac, cerebral, vascular and gastrointestinal admission diagnoses, with thresholds at 300 mmoL/L. For patients with respiratory disease, however, no significant association was detected.
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