Evidence map›Paper›PMID 28490503›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Entropic forces drive self-organization and membrane fusion by SNARE proteins.

Hakhamanesh Mostafavi, Sathish Thiyagarajan, Benjamin S Stratton, Erdem Karatekin, Jason M Warner, James E Rothman, Ben O'Shaughnessy

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 72 citations in OpenAlex.

  1. Munc13 serves as a molecular filter for SNARE sorting and assembly in active zone condensates.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Molecular Dynamics Simulation for Membrane Fusion.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  6. Review
  7. All SNAP25 molecules in the vesicle-plasma membrane contact zone change conformation during vesicle priming.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. The machinery of vesicle fusion.Current opinion in cell biology · 2023
    Review
  10. Article
  11. CHARMM-GUIJournal of chemical theory and computation · 2023
    Review
  12. Review
  13. Article
  14. Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Energetics, kinetics, and pathways of SNARE assembly in membrane fusion.Critical reviews in biochemistry and molecular biology · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hakhamanesh MostafaviDepartment of Chemical Engineering, Columbia University, New York, NY 10027.ORCID 0000-0002-1060-2844
Sathish ThiyagarajanDepartment of Physics, Columbia University, New York, NY 10027.ORCID 0000-0001-8545-8886
Benjamin S StrattonDepartment of Chemical Engineering, Columbia University, New York, NY 10027.
Erdem KaratekinDepartment of Cellular and Molecular Physiology, Yale School of Medicine, Yale University, New Haven, CT 06520.ORCID 0000-0002-5934-8728
Jason M WarnerDepartment of Chemical Engineering, Columbia University, New York, NY 10027.
James E RothmanNanobiology Institute, Yale University, West Haven, CT 06516; james.rothman@yale.edu bo8@columbia.edu.
Ben O'ShaughnessyDepartment of Chemical Engineering, Columbia University, New York, NY 10027; james.rothman@yale.edu bo8@columbia.edu.
Columbia University · USCentre National de la Recherche Scientifique · FRYale University · US

Funding

Regulation of Vesicle TrafficR35GM118084 · NIGMS · YALE UNIVERSITY · PI ROTHMAN, JAMES · 2016 to 2019
$3.4M
Nucleation and dynamics of exocytotic fusion poresR01GM108954 · NIGMS · YALE UNIVERSITY · PI KARATEKIN, ERDEM · 2014 to 2018
$1.6M
NIGMS NIH HHS R01 GM108954NIGMS NIH HHS R35 GM118084
6 · The paper itself

Abstract

SNARE proteins are the core of the cell's fusion machinery and mediate virtually all known intracellular membrane fusion reactions on which exocytosis and trafficking depend. Fusion is catalyzed when vesicle-associated v-SNAREs form

Indexed as

ExocytosisMembrane FusionModels, BiologicalEntropyMonte Carlo MethodSNARE ProteinsSNARE Proteinsentropic forceexocytosismembrane fusionneurotransmitter releaseSNARE

Identifiers

PMID28490503
PMCPMC5448213
OpenAlexW2612533220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.