Evidence map›Paper›PMID 28490488›Full record

ArticleJournal of clinical microbiology2017

Genetic and Epidemiologic Trends of Norovirus Outbreaks in the United States from 2013 to 2016 Demonstrated Emergence of Novel GII.4 Recombinant Viruses.

Jennifer L Cannon, Leslie Barclay, Nikail R Collins, Mary E Wikswo, Christina J Castro, Laura Cristal Magaña, Nicole Gregoricus, Rachel L Marine, Preeti Chhabra, Jan Vinjé

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 189 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 2 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 2 syntheses or guidelines pooled it, 280 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Global trends in norovirus genotype distribution among medically attended children with acute gastroenteritis, 2020-2025.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2026
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  7. Article
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  11. Molecular genetic characterisation of norovirus GII.17 strains circulating in South Korea in 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
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129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Jennifer L CannonCDC Foundation, Atlanta, Georgia, USA.
Leslie BarclayDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Nikail R CollinsAtlanta Research and Education Foundation, Decatur, Georgia, USA.
Mary E WikswoDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Christina J CastroOak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA.
Laura Cristal MagañaOak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA.
Nicole GregoricusDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Rachel L MarineDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Preeti ChhabraSynergy America, Inc., Atlanta, Georgia, USA.
Jan VinjéDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA jvinje@cdc.gov.
Centers for Disease Control and Prevention · USOak Ridge Associated Universities · USAtlanta Research and Education Foundation · USCDC Foundation · USSynergy America (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noroviruses are the most frequent cause of epidemic acute gastroenteritis in the United States. Between September 2013 and August 2016, 2,715 genotyped norovirus outbreaks were submitted to CaliciNet. GII.4 Sydney viruses caused 58% of the outbreaks during these years. A GII.4 Sydney virus with a novel GII.P16 polymerase emerged in November 2015, causing 60% of all GII.4 outbreaks in the 2015-2016 season. Several genotypes detected were associated with more than one polymerase type, including GI.3, GII.2, GII.3, GII.4 Sydney, GII.13, and GII.17, four of which harbored GII.P16 polymerases. GII.P16 polymerase sequences associated with GII.2 and GII.4 Sydney viruses were nearly identical, suggesting common ancestry. Other common genotypes, each causing 5 to 17% of outbreaks in a season, included GI.3, GI.5, GII.2, GII.3, GII.6, GII.13, and GII.17 Kawasaki 308. Acquisition of alternative RNA polymerases by recombination is an important mechanism for norovirus evolution and a phenomenon that was shown to occur more frequently than previously recognized in the United States. Continued molecular surveillance of noroviruses, including typing of both polymerase and capsid genes, is important for monitoring emerging strains in our continued efforts to reduce the overall burden of norovirus disease.

Indexed as

Disease OutbreaksGenotypeCaliciviridae InfectionsCapsid ProteinsHumansMolecular EpidemiologyNorovirusRNA-Dependent RNA PolymeraseUnited StatesCapsid ProteinsRNA-Dependent RNA Polymerasegenetic recombinationgenotypic identificationnoroviruses

Identifiers

PMID28490488
PMCPMC5483924
OpenAlexW2612775808

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.