SynthesisJournal of epidemiology and community health2017
Socioeconomic status in childhood and C reactive protein in adulthood: a systematic review and meta-analysis.
Synthesis in Journal of epidemiology and community health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The intergenerational effects of low parental socio-economic position on cardiometabolic and inflammatory outcomes: A systematic review and meta-analysis.European journal of clinical investigation · 2026Pooled it
- Externalizing trajectories predict elevated inflammation among adolescents exposed to early institutional rearing: A randomized clinical trial.Psychoneuroendocrinology · 2019Trial
- Income and risk of type 2 diabetes incidence varied associations according to obesity status: a nationwide study.BMC public health · 2026Article
- Educational level, clinical outcomes and quality of care in a Swiss cohort of patients with acute coronary syndromes.European journal of clinical investigation · 2025Article
- Ageing Trajectories: Exposome-Driven Pathobiological Mechanisms and Implications for Prevention from Blue Zones and Italian Longevity Hotspots Such as Cilento and Sicilian Mountain Villages.International journal of molecular sciences · 2025Review
- Mediators of the Association Between Child Education and Adult Health.JAMA network open · 2025Article
- Socioeconomic position interacts with the genetic effect of a CRP gene common variant to influence C-reactive protein values.Scientific reports · 2024Article
- Socioeconomic status across the early life course predicts gene expression signatures of disease and senescence.Journal of epidemiology and community health · 2024Article
- Socioeconomic Disadvantage, Neighborhood Belonging, and Inflammation Among Adolescents.Psychosomatic medicine · 2024Article
- Socioeconomic Status and Obesity.Journal of the Endocrine Society · 2024Review
- Associations between dietary diversity and high sensitive C-reactive protein among Japanese workers: findings of a cross-sectional and longitudinal study.European journal of nutrition · 2024Article
- Exposure to parental depression in adolescence and proinflammatory phenotypes 20 years later.Brain, behavior, and immunity · 2024Article
- Overadjustment bias in systematic reviews and meta-analyses of socio-economic inequalities in health: a meta-research scoping review.International journal of epidemiology · 2024Article
- Socioeconomic inequalities in early adulthood disrupt the immune transcriptomic landscape via upstream regulators.Scientific reports · 2024Article
- Family income as a moderator of relations between sleep and physical health during adolescence.Sleep health · 2023Article
- The association between socioeconomic status and C-reactive protein in Bayesian perspective.SSM - population health · 2023Article
- Positive Childhood Experiences and Adult Health Outcomes.Pediatrics · 2023Article
- The impact of social and environmental factors on cancer biology in Black Americans.Cancer causes & control : CCC · 2023Review
- Systemic Inflammation Contributes to the Association Between Childhood Socioeconomic Disadvantage and Midlife Cardiometabolic Risk.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Article
- PTSD, Immune System, and Inflammation.Advances in experimental medicine and biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundInflammation plays a central role in cardiometabolic disease and may represent a mechanism linking low socioeconomic status (SES) in early life and adverse cardiometabolic health outcomes in later life. Accumulating evidence suggests an association between childhood SES and adult inflammation, but findings have been inconsistent.
methodsWe conducted a systematic review and meta-analysis of observational studies to quantify the association between childhood (age <18 years) SES and the inflammatory marker C reactive protein (CRP) in adulthood. Studies were identified in Medline and Embase databases, and by reviewing the bibliographies of articles published from 1946 to December 2015. Study-specific estimates were combined into meta-analyses using random-effects models.
results15 of 21 eligible studies (n=43 629) were ultimately included in two separate meta-analyses. Compared with those from the most advantaged families, participants from the least advantaged families had 25% higher CRP levels (ratio change in geometric mean CRP: 1.25; 95% CI 1.19 to 1.32) in minimally adjusted analyses. This finding was attenuated by the inclusion of adult body mass index (BMI) in adjusted models, suggesting BMI has a strong mediating role in CRP levels.
conclusionsWe observed an inverse association between childhood SES and adulthood CRP, potentially mediated through BMI. Investigating how childhood SES is associated with childhood BMI and CRP would provide insight into the effective timing of social and clinical interventions to prevent cardiometabolic disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.