Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2017
Perioperative COX-2 and β-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial.
4 registry-linked trialsOpen access · greenAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 163 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 3 pooled it
17.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perioperative Use of a Beta-adrenergic Blocker and a COX-2 Inhibitor in Patients Undergoing Surgery With Primary Pancreatic Cancer: Intervention Aiming to Reduce Pro-metastatic Processes
Perioperative Use of a β-adrenergic Blocker, Propranolol, and a COX2 Inhibitor, Etodolac, in Patients Undergoing Resection With Curative Intent for Primary Colon and Rectal Cancer: Effect on Tumor Recurrence and Survival
Perioperative Propranolol in Robotic Assisted Laparoscopic Prostatectomy- A Feasibility Study of Propranolol to Target Perioperative Stress Induced Cancer Progression
Inhibiting Beta-adrenergic and COX-2 Signaling During the Perioperative Period to Reduce Ovarian Cancer Progression: A Randomized Placebo-Controlled Clinical Trial
Who cites it
163 citing papers in PubMed, 3 syntheses or guidelines pooled it, 258 citations in OpenAlex.
- Does propranolol have a role in cancer treatment? A systematic review of the epidemiological and clinical trial literature on beta-blockers.Journal of cancer research and clinical oncology · 2025Pooled it
- Perioperative systemic nonsteroidal anti-inflammatory drugs (NSAIDs) in women undergoing breast surgery.The Cochrane database of systematic reviews · 2021Pooled it
- β-Blocker use is not associated with improved clinical outcomes in women with breast cancer: a meta-analysis.Bioscience reports · 2020Pooled it
- Impact of opioid-free general anesthesia with locoregional blocks during breast cancer surgery on systemic inflammatory response: results from a randomized controlled trial.Regional anesthesia and pain medicine · 2026Trial
- Favorable safety outcomes of a perioperative propranolol and etodolac regimen in cancer patients in four randomized controlled trials.Frontiers in pharmacology · 2026Trial
- Effect of Perioperative Interleukin-6 and Tumor Necrosis Factor-Journal of immunology research · 2022Trial
- Propranolol inhibits molecular risk markers in HCT recipients: a phase 2 randomized controlled biomarker trial.Blood advances · 2020Trial
- Prospective pilot trial with combination of propranolol with chemotherapy in patients with epithelial ovarian cancer and evaluation on circulating immune cell gene expression.Gynecologic oncology · 2019Trial
- Intraoperative ketorolac in high-risk breast cancer patients. A prospective, randomized, placebo-controlled clinical trial.PloS one · 2019Trial
- Trial
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Review
- Neural-tumor interactions: bidirectional regulatory mechanisms and nervous system-targeted tumor therapeutic strategies.Biomarker research · 2026Review
- Cancer Neuroscience: From Local Neuro-Immune Microenvironments to Systemic Brain-Body Circuitry.MedComm · 2026Review
- Perioperative propranolol during robotic-assisted radical prostatectomy: A randomised, double-blind, placebo-controlled, pilot trial (PeP-RALP).BJUI compass · 2026Article
- Postoperative wound microenvironment regulates breast cancer stem cell fate and clinical implications.Molecular biology reports · 2026Review
- Neural regulation of cancer: from microenvironmental hijacking to systemic circuit co-option.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Stress‑induced catecholamines attenuate sorafenib efficacy by inhibiting ferroptosis in β2‑adrenergic receptor positive renal cell carcinoma.International journal of oncology · 2026Article
- Depression remodels tumor microenvironment to drive tumor progression: Bio-behavioural signalling pathways and clinical interventions.Journal of advanced research · 2026Review
- Perioperative psycho-behavioral stress promotes cancer metastasis beyond the impact of surgery: Neuroendocrine and tumor molecular mediating mechanisms.Brain, behavior, & immunity - health · 2026Article
103 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 2 countries.
Lee ShaashuaSagol School of Neuroscience and School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
Maytal Shabat-SimonSagol School of Neuroscience and School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
Rita HaldarSagol School of Neuroscience and School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
Pini MatznerSagol School of Neuroscience and School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
Oded ZmoraDepartment of Surgery and Transplantation, Sheba Medical Center, Ramat Gan, Israel.
Moshe ShabtaiDepartment of Surgery and Transplantation, Sheba Medical Center, Ramat Gan, Israel.
Eran SharonDepartment of Surgery, Rabin Medical Center, Beilinson Hospital, Petach-Tikva, Israel.
Tanir AllweisDepartment of Surgery, Kaplan Medical Center, Rehovot, Israel.
Iris BarshackDepartment of Pathology, Sheba Medical Center, Ramat Gan, Israel.
Lucile HaymanDepartment of Pathology, Rabin Medical Center, Petah Tikva, Israel.
Jesusa ArevaloDepartments of Medicine and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California.
Jeffrey MaDepartments of Medicine and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California.
Maya HorowitzSagol School of Neuroscience and School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
Steven ColeDepartments of Medicine and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California.
Shamgar Ben-EliyahuSagol School of Neuroscience and School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel. shamgar@post.tau.ac.il.
Tel Aviv University · ILNeurobehavioral Systems · USSheba Medical Center · ILRabin Medical Center · ILKaplan Medical Center · IL
Funding
USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, HIRAM BELTRAN-SANCHEZ · 1999 to 2026
$17.9MSocial regulation of pro-inflammatory monocytesR01AG043404 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, STEVE W · 2014 to 2018
$1.6MNIA NIH HHS P30 AG017265NIA NIH HHS R01 AG043404
Abstract
PubMed holds no abstract for this paper.
Indexed as
Gene Expression ProfilingAdrenergic beta-AntagonistsAdultAgedAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorBreast NeoplasmsCyclooxygenase 2 InhibitorsDouble-Blind MethodEtodolacFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedNeoplasm MetastasisPerioperative PeriodAdrenergic beta-AntagonistsBiomarkers, TumorCyclooxygenase 2 InhibitorsEtodolacPropranololTranscription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT03838029ClinicalTrials.gov
NCT03919461ClinicalTrials.gov
NCT05679193ClinicalTrials.gov
NCT06839144ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.