Evidence map›Paper›PMID 28490452›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017

Role of endothelial nitric oxide in control of peripheral vascular conductance during muscle metaboreflex activation.

Danielle Senador, Jasdeep Kaur, Alberto Alvarez, Hanna W Hanna, Abhinav C Krishnan, Yasir H Altamimi, Donal S O'Leary

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. 3D Bioprinting: from Benches to Translational Applications.Small (Weinheim an der Bergstrasse, Germany) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Danielle SenadorDepartment of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
Jasdeep KaurDepartment of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
Alberto AlvarezDepartment of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
Hanna W HannaDepartment of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
Abhinav C KrishnanDepartment of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
Yasir H AltamimiDepartment of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
Donal S O'LearyDepartment of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan doleary@med.wayne.edu.
Wayne State University · US

Funding

BLOOD PRESSURE CONTROL DURING EXERCISE IN HEART FAILURER01HL055473 · NHLBI · WAYNE STATE UNIVERSITY · PI O'LEARY, DONAL S · 1996 to 2024
$9.8M
Mechanisms Mediating Enhanced Sympatho-Activation During Exercise in HypertensionR01HL126706 · NHLBI · WAYNE STATE UNIVERSITY · PI O'LEARY, DONAL S · 2016 to 2019
$2.2M
NHLBI NIH HHS R01 HL055473NHLBI NIH HHS R01 HL126706
6 · The paper itself

Abstract

The muscle metaboreflex is a powerful pressor reflex induced by the activation of chemically sensitive muscle afferents as a result of metabolite accumulation. During submaximal dynamic exercise, the rise in arterial pressure is primarily due to increases in cardiac output, since there is little systemic vasoconstriction. Indeed, in normal animals, we have often shown a small, but significant, peripheral vasodilation during metaboreflex activation, which is mediated, at least in part, by release of epinephrine and activation of vascular β

Indexed as

Electric ConductivityAnimalsDogsEndothelium, VascularFemaleMaleMuscle, SkeletalNitric OxideReflexNitric Oxideexercise pressor reflexnonischemic vasculaturevasodilation

Identifiers

PMID28490452
PMCPMC5538851
OpenAlexW2613778183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.