ArticleBMC cardiovascular disorders2017
The clinical epidemiology of fatigue in newly diagnosed heart failure.
Article in BMC cardiovascular disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Fatigue in Persons With Heart Failure: A Systematic Literature Review and Meta-Synthesis Using the Biopsychosocial Model of Health.Journal of cardiac failure · 2022Pooled it
- Validation of the STOP-Bang questionnaire as a screening tool for obstructive sleep apnoea in patients with cardiovascular risk factors: a systematic review and meta-analysis.BMJ open respiratory research · 2021Pooled it
- Fatigue after pulmonary embolism-prevalence and predictors.Frontiers in cardiovascular medicine · 2026Article
- Article
- Measuring health-related quality of life in cardiovascular disease using a novel patient-centred and disease-specific patient-reported outcome measure.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Predictive Factors and Risk Assessment for Hospitalization in Chest Pain Patients Admitted to the Emergency Department.Diagnostics (Basel, Switzerland) · 2024Article
- Development of a PROMIS multidimensional cancer-related fatigue (mCRF) form using modern psychometric techniques.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Identification of Fatigue Subtypes and Their Correlates in Prevalent Heart Failure: A Secondary Analysis of the Atherosclerosis Risk in Communities Study.Circulation. Cardiovascular quality and outcomes · 2024Article
- Consideration of Symptom Management in Advanced Heart Failure.International journal of environmental research and public health · 2022Article
- New perspective on fatigue in hemodialysis patients with preserved ejection fraction: diastolic dysfunction : Fatigue and diastolic dysfunction.The international journal of cardiovascular imaging · 2022Article
- Associations of Chronic Diabetes Complications and Cardiovascular Risk with the Risk of Obstructive Sleep Apnea in Patients with Type 2 Diabetes.Journal of clinical medicine · 2022Article
- Article
- Sleep Deficiency: A Symptoms Perspective: Exemplars from Chronic Heart Failure, Inflammatory Bowel Disease, and Breast Cancer.Clinics in chest medicine · 2022Review
- Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study.Scientific reports · 2021Article
- Palliative Care for People Living With Heart Disease-Does Sex Make a Difference?Frontiers in cardiovascular medicine · 2021Review
- Palliative Care in Acute Heart Failure.Current heart failure reports · 2020Review
- Validation of the Multidimensional Fatigue Inventory with Coronary Artery Disease Patients.International journal of environmental research and public health · 2020Article
- Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease.Journal of clinical medicine · 2018Article
- Sleep-disordered breathing in patients with cardiovascular diseases cannot be detected by ESS, STOP-BANG, and Berlin questionnaires.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- The Associations of Diagnoses of Fatigue and Depression With Use of Medical Services in Patients With Heart Failure.The Journal of cardiovascular nursingArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFatigue is a common and distressing but poorly understood symptom among patients with heart failure (HF). This study sought to evaluate the prevalence, predictors, and prognostic value of clinically documented fatigue in newly diagnosed HF patients from the community.
methodsThis retrospective cohort study consisted of 12,285 newly diagnosed HF patients receiving health care services through the Geisinger Health System, with passive data collection through electronic medical records (EMR). Incident HF, fatigue, and other study variables were derived from coded data within EMRs. A collection of 87 candidate predictors were evaluated to ascertain the strongest independent predictors of fatigue using logistic regression. Patients were followed for all-cause mortality for an average of 4.8 years. The associations between fatigue and 6-month, 12-month, and overall mortality were evaluated via Cox proportional hazards regression models.
resultsClinically documented fatigue was found in 4827 (39%) newly diagnosed HF patients. Depression demonstrated the strongest association with fatigue. Fatigue was often part of a symptom cluster, as other HF symptoms including dyspnea, chest pain, edema, syncope, and palpitations were significant predictors of fatigue. Volume depletion, lower body mass index, and abnormal weight loss were also strong predictors of fatigue. Fatigue was not significantly associated with either 6-month (HR = 1.12, p = 0.16) or overall mortality (HR = 1.00, p = 0.89) in adjusted models.
conclusionsFatigue is a commonly documented symptom among newly diagnosed HF patients, and its origins may lie in both psychologic and physiologic factors. Though fatigue did provide a prognostic signal in the short-term, this was largely explained by physiologic confounders. Proper therapeutic remediation of fatigue in HF relies on identifying underlying factors.
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