Evidence map›Paper›PMID 28490256›Full record

ArticleStem cells and development2017

How Plastic Are Pericytes?

Alexander Birbrair, Isabella da Terra Borges, Isadora Fernandes Gilson Sena, Gregório Guilherme Almeida, Lindolfo da Silva Meirelles, Ricardo Gonçalves, Akiva Mintz, Osvaldo Delbono

Abstract read
In one paragraph

Article in Stem cells and development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Biology of vascular mural cells.Development (Cambridge, England) · 2023
    Review
  9. Review
  10. Glioma Pericytes Promote Angiogenesis by Producing Periostin.Cellular and molecular neurobiology · 2022
    Review
  11. Article
  12. Review
  13. Circulating Nestin-GFPStem cell reviews and reports · 2021
    Article
  14. Review
  15. Sensory nerves in the spotlight of the stem cell niche.Stem cells translational medicine · 2021
    Review
  16. Article
  17. Review
  18. Article
  19. Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications.Frontiers in cell and developmental biology · 2020
    Review
  20. Neural stem cell niche heterogeneity.Seminars in cell & developmental biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alexander Birbrair1 Department of Pathology, Federal University of Minas Gerais , Belo Horizonte, MG, Brazil .
Isabella da Terra Borges1 Department of Pathology, Federal University of Minas Gerais , Belo Horizonte, MG, Brazil .
Isadora Fernandes Gilson Sena1 Department of Pathology, Federal University of Minas Gerais , Belo Horizonte, MG, Brazil .
Gregório Guilherme Almeida1 Department of Pathology, Federal University of Minas Gerais , Belo Horizonte, MG, Brazil .
Lindolfo da Silva Meirelles4 Laboratory for Stem Cells and Tissue Engineering, Lutheran University of Brazil , Canoas, Brazil .
Ricardo Gonçalves1 Department of Pathology, Federal University of Minas Gerais , Belo Horizonte, MG, Brazil .
Akiva Mintz5 Department of Radiology, Wake Forest School of Medicine , Winston-Salem, North Carolina.
Osvaldo Delbono6 Department of Internal Medicine-Gerontology, Wake Forest School of Medicine , Winston-Salem, North Carolina.
Universidade Federal de Minas Gerais · BRWake Forest University · USUniversidade Luterana do Brasil · BR

Funding

Tropin T and Excitation-Contraction Coupling in Aging Skeletal MuscleR01AG013934 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELBONO, OSVALDO · 2001 to 2017
$4.7M
Therapeutically Exploiting a Newly Isolated Neural-Like Stem Cell Against GSBR01CA179072 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2015 to 2020
$1.6M
NCI NIH HHS R01 CA179072NIA NIH HHS R01 AG013934
6 · The paper itself

Abstract

Pericytes are defined by both their anatomical location and molecular markers. Numerous publications have reported their role as stem cells, contributing to the formation of tissues other than blood vessels. However, using cell-lineage tracing in a new transgenic mouse model, a recent study shows that in the context of aging and some pathologies, Tbx18+ pericytes do not function as stem cells in vivo. This study challenges the current view that pericytes can differentiate into other cells and reopen questions about their plasticity. This emerging knowledge is important not only for our understanding of development but may also inform treatments for diseases.

Indexed as

Cell PlasticityAnimalsCell LineageHumansMiceModels, BiologicalPericytesStem Cellspericytesplasticityregenerationstem cells

Identifiers

PMID28490256
PMCPMC5512298
OpenAlexW2613513416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.