ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS
Molecular remodeling of the renin-angiotensin system after kidney transplantation.
Article in Journal of the renin-angiotensin-aldosterone system : JRAAS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Safety of ACEI/ARB use in the early (<3 months) post kidney transplant period: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Physiologic homeostasis after pig-to-human kidney xenotransplantation.Kidney international · 2024Article
- Intra- and postoperative relative angiotensin II deficiency in patients undergoing elective major abdominal surgery.Frontiers in endocrinology · 2024Observational
- Renin-angiotensin system inhibitor discontinuation in COVID-19 did not modify systemic ACE2 in a randomized controlled trial.iScience · 2023Article
- The systemic renin-angiotensin system in COVID-19.Scientific reports · 2022Article
- Relationship between the renin-angiotensin-aldosterone system and renal Kir5.1 channels.Clinical science (London, England : 1979) · 2019Article
- Progression of diabetic kidney disease in T2DN rats.American journal of physiology. Renal physiology · 2019Article
- Intrarenal Renin-Angiotensin-System Dysregulation after Kidney Transplantation.Scientific reports · 2019Article
- Postprandial Effects on ENaC-Mediated Sodium Absorption.Scientific reports · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed at assessing the molecular adaptation of the renin-angiotensin system (RAS) after successful kidney transplantation (KTX). MATERIALS AND
methodsIn this prospective, exploratory study we analyzed 12 hemodialysis (HD) patients, who received a KTX and had excellent graft function six to 12 months thereafter. The concentrations of plasma Angiotensin (Ang) peptides (Ang I, Ang II, Ang-(1-7), Ang-(1-5), Ang-(2-8), Ang-(3-8)) were simultaneously quantified with a novel mass spectrometry-based method. Further, renin and aldosterone concentrations were determined by standard immunoassays.
resultsAng values showed a strong inter-individual variability among HD patients. Yet, despite a continued broad dispersion of Ang values after KTX, a substantial improvement of the renin/Ang II correlation was observed in patients without RAS blockade or on angiotensin receptor blocker (HD: renin/Ang II R
conclusionsFollowing KTX, renin-dependent Ang II formation adapts in non-ACE inhibitor-treated patients. Thus, a largely normal RAS regulation is reconstituted after successful KTX. However, individual Ang concentration variations and a lack of potentially beneficial alternative peptides after KTX call for individualized treatment. The long-term post-transplant RAS regulation remains to be determined.
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