Evidence map›Paper›PMID 28489961›Full record

ReviewSmall GTPases2019

The role of Exo70 in exocytosis and beyond.

Yueyao Zhu, Bin Wu, Wei Guo

Open access · bronzeAbstract readReviewVideo-Audio Media
In one paragraph

Review in Small GTPases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Genome-wide identification of theFrontiers in plant science · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Emerging Roles of Exocyst Complex in Fungi: A Review.Journal of fungi (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. The Upregulated Expression of the CitrusInternational journal of molecular sciences · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yueyao Zhua Department of Biology, University of Pennsylvania , Philadelphia , PA , USA.
Bin Wua Department of Biology, University of Pennsylvania , Philadelphia , PA , USA.
Wei Guoa Department of Biology, University of Pennsylvania , Philadelphia , PA , USA.
University of Pennsylvania · US

Funding

The Role of the Exocyst in Cell MigrationR01GM085146 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GUO, WEI · 2009 to 2020
$4.1M
Molecular Regulation of ExocytosisR01GM111128 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GUO, WEI · 2014 to 2020
$2.4M
NIGMS NIH HHS R01 GM085146NIGMS NIH HHS R01 GM111128
6 · The paper itself

Abstract

The exocyst complex mediates the tethering of secretory vesicles to the plasma membrane before SNARE-mediated membrane fusion. Recent studies have implicated the exocyst in a wide range of cellular processes. Particularly, research on the Exo70 subunit of the complex has linked the function of the exocyst in exocytosis to cell adhesion, migration and invasion. In this review, we will discuss the recent work on how Exo70 regulates these cellular processes, and how small GTPases and kinases interact with Exo70 to orchestrate its function in exocytosis and cytoskeleton organization. The study of Exo70 contributes to the understanding of many pathophysiological processes from organogenesis to cancer metastasis.

Indexed as

ExocytosisOrganogenesisAnimalsCell AdhesionCell MovementCytoskeletonHumansNeoplasm InvasivenessNeoplasm MetastasisNeoplasm ProteinsNeoplasmsSNARE ProteinsVesicular Transport ProteinsEXOC7 protein, humanNeoplasm ProteinsSNARE ProteinsVesicular Transport Proteinscell adhesioncell invasioncell migrationExo70exocystinvadopodialamellipodia

Identifiers

PMID28489961
PMCPMC6748379
OpenAlexW2614047906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.