ArticlePloS one2017
Cortical involvement in celiac disease before and after long-term gluten-free diet: A Transcranial Magnetic Stimulation study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- The Neurophysiological Responses of Concussive Impacts: A Systematic Review and Meta-Analysis of Transcranial Magnetic Stimulation Studies.Frontiers in human neuroscience · 2020Pooled it
- Transcranial magnetic stimulation in the assessment of acupuncture effect on exercise-induced fatigue.Brain and behavior · 2024Trial
- Cortical inhibition in neurofibromatosis type 1 is modulated by lovastatin, as demonstrated by a randomized, triple-blind, placebo-controlled clinical trial.Scientific reports · 2022Trial
- Beyond gluten-free diet: Novel therapeutic frontiers in celiac disease armamentarium.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Transcranial Magnetic Stimulation in Parkinson's Disease and Parkinsonian Syndromes: A Narrative Expert Review.Life (Basel, Switzerland) · 2026Review
- Celiac disease as a model of gut-brain autoimmunity: from gluten exposure to neuropsychiatric manifestations.Frontiers in pediatrics · 2026Review
- Odontophobia Across the Lifespan: Clinical Perspectives, Vulnerable Populations, and Inclusive Strategies for Dental Anxiety Management.Journal of clinical medicine · 2025Article
- Most prominent challenges in translational neuroscience and strategic solutions to bridge the gaps: Perspectives from an editorial board interrogation.Exploration of neuroscience · 2025Article
- Challenging the Pleiotropic Effects of Repetitive Transcranial Magnetic Stimulation in Geriatric Depression: A Multimodal Case Series Study.Biomedicines · 2023Article
- Editorial: Nutrients and brain: from bench to the bedside.Frontiers in human neuroscience · 2023Article
- Sex differences in mild vascular cognitive impairment: A multimodal transcranial magnetic stimulation study.PloS one · 2023Article
- Sex-specific reference values for total, central, and peripheral latency of motor evoked potentials from a large cohort.Frontiers in human neuroscience · 2023Article
- Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation.International journal of molecular sciences · 2022Review
- Reduced Intracortical Facilitation to TMS in Both Isolated REM Sleep Behavior Disorder (RBD) and Early Parkinson's Disease with RBD.Journal of clinical medicine · 2022Article
- Cerebral hemodynamic changes to transcranial Doppler sonography in celiac disease: A pilot study.Frontiers in human neuroscience · 2022Article
- A comprehensive review of transcranial magnetic stimulation in secondary dementia.Frontiers in aging neuroscience · 2022Review
- Motor Cortex Response to Pleasant Odor Perception and Imagery: The Differential Role of Personality Dimensions and Imagery Ability.Frontiers in human neuroscience · 2022Article
- Motor Cortex Excitation/Inhibition Imbalance in Young Adults With Autism Spectrum Disorder: A MRS-TMS Approach.Frontiers in psychiatry · 2022Article
- Impact of COVID-19 pandemic on the neuropsychiatric status of Wilson's disease.World journal of gastroenterology · 2021Article
- Glycine receptor antibodies and coeliac disease-related neurological dysfunction.Cerebellum & ataxias · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTranscranial Magnetic Stimulation in de novo patients with Celiac Disease previously revealed an imbalance in the excitability of cortical facilitatory and inhibitory circuits. After a median period of 16 months of gluten-free diet, a global increase of cortical excitability was reported, suggesting a glutamate-mediated compensation for disease progression. We have now evaluated cross-sectionally the changes of cortical excitability to TMS after a much longer gluten-free diet.
methodsTwenty patients on adequate gluten-free diet for a mean period of 8.35 years were enrolled and compared with 20 de novo patients and 20 healthy controls. Transcranial Magnetic Stimulation measures, recorded from the first dorsal interosseous muscle of the dominant hand, consisted of: resting motor threshold, cortical silent period, motor evoked potentials, central motor conduction time, mean short-latency intracortical inhibition and intracortical facilitation.
resultsThe cortical silent period was shorter in de novo patients, whereas in gluten-free diet participants it was similar to controls. The amplitude of motor responses was significantly smaller in all patients than in controls, regardless of the dietary regimen. Notwithstanding the diet, all patients exhibited a statistically significant decrease of mean short-latency intracortical inhibition and enhancement of intracortical facilitation with respect to controls; more intracortical facilitation in gluten-restricted compared to non-restricted patients was also observed. Neurological examination and celiac disease-related antibodies were negative.
conclusionsIn this new investigation, the length of dietary regimen was able to modulate the electrocortical changes in celiac disease. Nevertheless, an intracortical synaptic dysfunction, mostly involving excitatory and inhibitory interneurons within the motor cortex, may persist. The clinical significance of subtle neurophysiological changes in celiac disease needs to be further investigated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.