Evidence map›Paper›PMID 28489914›Full record

ArticlePloS one2017

miR-27a and miR-449b polymorphisms associated with a risk of idiopathic recurrent pregnancy loss.

HyungChul Rah, Ki Wha Chung, Ki Han Ko, Eun Sun Kim, Jung Oh Kim, Jung Hyun Sakong, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  16. Biomolecular Markers of Recurrent Implantation Failure-A Review.International journal of molecular sciences · 2021
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  17. Association betweenInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

HyungChul RahDepartment of Business Data Convergence, Chungbuk National University, Cheongju, South Korea.
Ki Wha ChungDepartment of Biological Science, College of Natural Science, Kongju National University, Gongju, South Korea.
Ki Han KoDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Eun Sun KimDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Jung Oh KimDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Jung Hyun SakongDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Ji Hyang KimDepartment of Obstetrics and Gynecology and Fertility Center of CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Woo Sik LeeFertility Center of CHA Gangnam Medical Center, CHA University, Seoul, South Korea.
Nam Keun KimDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.ORCID http://orcid.org/0000-0003-0541-3528
CHA University · KRCHA University Bundang Medical Center · KRChungbuk National University · KRKongju National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMicroRNAs (miRNAs) regulate gene expression during the peri-implantation period. The purpose of this study was to investigate whether genetic polymorphisms in the four miRNAs associated with fetal or placental development play roles in the development of idiopathic recurrent pregnancy loss (RPL) in Korean females. STUDY

designA case-control study involving 225 controls and 387 women with at least two consecutively recurrent pregnancy losses between 1999 and 2012 was performed. The genotypes of the four miRNA polymorphisms, including miR-27a rs895819, miR-423 rs6505162, miR-449b rs10061133, and miR-605 rs2043556, were analyzed by the polymerase chain reaction-restriction fragment length polymorphism assay. Odds ratios and 95% confidence intervals were estimated using multivariate analyses after maternal age adjustments. The relationships between each of the four microRNA genotypes and each of the six clinical parameters of the RPL patients (plasma homocysteine and folate levels, natural killer cell number, platelet count, prothrombin time, and, activated partial thromboplastin time) were analyzed using multiple linear regression analyses.

resultsOur results suggest that weak associations between decreased RPL risk and the genotypes of miR-27a (AG and AG+GG), combination genotype of miR-27a/miR-423 (AG/GC), and haplotypes of miR-27a/miR-423/miR-449b/miR-605 (G-C-A-G) and miR-27a/miR-449b/miR-605 (G-A-G), whereas weak associations between increased RPL risk and genotypes of miR-449b (GG and AG+GG), combination genotypes of miR-423/miR-449b (CC/GG and CA/AG), miR-449b/miR-605 (AG/AG), haplotypes of miR-27a/miR-423/miR-449b/miR-605 (A-C-G-A, A-A-A-G, and G-C-G-G), miR-27a/miR-423/miR-449b (A-C-G), miR-27a/miR-449b/miR-605 (A-A-G, A-G-A, and G-G-G), miR-423/miR-449b/miR-605 (C-G-G and A-A-G), and miR-423/miR-449b (C-G and A-A). The genotypes of miR-27a (AG and AG+GG) also showed significant contributions to the prediction of folate levels in RPL patients.

conclusionsThe study showed associations between miRNA polymorphisms (miR-27a rs895819 and miR-449b rs10061133) and RPL development, and between the miRNA polymorphism (miR-27a rs895819) and plasma folate levels.

Indexed as

Polymorphism, GeneticAbortion, HabitualAdultAsian PeopleBlood CoagulationCase-Control StudiesCholesterolFemaleFolic AcidGenotypeHumansMicroRNAsPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotidePregnancyRepublic of KoreaCholesterolFolic AcidMicroRNAsMIRN27 microRNA, humanMIRN423 microRNA, humanMIRN449 microRNA, humanMIRN605 microRNA, humanUric Acid

Identifiers

PMID28489914
PMCPMC5425187
OpenAlexW2612620841

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.