Evidence map›Paper›PMID 28489884›Full record

ArticlePloS one2017

Comparison of the prognostic values of preoperative inflammation-based parameters in patients with breast cancer.

Hideya Takeuchi, Hirohumi Kawanaka, Seiichi Fukuyama, Nobuhide Kubo, Shoji Hiroshige, Tokujiro Yano

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hideya TakeuchiDepartment of Surgery, National Hospital Organization Beppu Medical Center, Beppu, Oita, Japan.ORCID http://orcid.org/0000-0001-6847-4518
Hirohumi KawanakaDepartment of Surgery, National Hospital Organization Beppu Medical Center, Beppu, Oita, Japan.
Seiichi FukuyamaDepartment of Surgery, National Hospital Organization Beppu Medical Center, Beppu, Oita, Japan.
Nobuhide KuboDepartment of Surgery, National Hospital Organization Beppu Medical Center, Beppu, Oita, Japan.
Shoji HiroshigeDepartment of Surgery, National Hospital Organization Beppu Medical Center, Beppu, Oita, Japan.
Tokujiro YanoDepartment of Surgery, National Hospital Organization Beppu Medical Center, Beppu, Oita, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral blood-derived inflammation-based markers, including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are indicators of prognosis in various malignant tumors. The present study aimed to identify the inflammation-based parameters that are most suitable for predicting outcomes in patients with breast cancer. Two hundred ninety-six patients who underwent surgery for localized breast cancer were reviewed retrospectively. The association between clinicopathological factors and inflammation-based parameters were investigated. Univariate and multivariate Cox regression analyses were performed to identify independent prognostic indicators associated with disease-free survival (DFS). The NLR level correlated significantly with tumor size (P<0.05). The PLR level correlated with the expression of estrogen receptor and lymph node involvement (P<0.05). Univariate analysis revealed that lower CRP and PLR values as well as tumor size, lymph node involvement, and nuclear grade were significantly associated with superior DFS (CRP: P<0.01; PLR, tumor size, lymph node involvement, and nuclear grade: P<0.05). On multivariate analysis, CRP (hazard ratio [HR]: 2.85, 95% confidence interval [CI]: 1.03-7.88, P<0.05), PLR (HR: 2.61, 95% CI: 1.07-6.36, P<0.05) and nuclear grade (HR: 3.066, 95% CI: 1.26-7.49, P<0.05) were significant prognostic indicators of DFS in patients with breast cancer. Neither LMR nor NLR significantly predicted DFS. Both preoperative CRP and PLR values were independently associated with poor prognosis in patients with breast carcinoma; these were superior to other inflammation-based scores in terms of prognostic ability.

Indexed as

BreastBreast NeoplasmsC-Reactive ProteinDisease-Free SurvivalFemaleHumansLymphocyte CountMiddle AgedMultivariate AnalysisPlatelet CountPreoperative PeriodPrognosisProportional Hazards ModelsRetrospective StudiesC-Reactive Protein

Identifiers

PMID28489884
PMCPMC5425200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.