ArticlePLoS neglected tropical diseases2017
Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- A Class IInfection and immunity · 2019Trial
- Investigation of bacterial agents in yaws-like ulcers in children and their environment in Cameroon: An experience from the Akonolinga Health District.PLoS neglected tropical diseases · 2026Article
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- High Prevalence of Haemophilus ducreyi Among Patients With Suspected Primary syphilis in Malawi, 2019-2022.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Assessment of the role of Haemophilus ducreyi coinfection on outcomes of Yaws treatment in the southwestern part of Ghana.PLoS neglected tropical diseases · 2026Article
- Mapping the distribution of yaws and Haemophilus ducreyi in the western north region of Ghana.BMC infectious diseases · 2025Observational
- The protein degradation system encoded byInfection and immunity · 2025Article
- Detection of Haemophilus ducreyi from environmental and animal samples in Cameroon.PLoS neglected tropical diseases · 2025Article
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- Infections caused byClinical microbiology reviews · 2024Review
- AInfection and immunity · 2024Article
- Transmission of viable Haemophilus ducreyi by Musca domestica.PLoS neglected tropical diseases · 2024Article
- High prevalence and genetic diversity ofMicrobiology spectrum · 2024Article
- Prevalence and risk factors associated with Haemophilus ducreyi cutaneous ulcers in Cameroon.PLoS neglected tropical diseases · 2023Article
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- Ulcerative skin lesions among children in Cameroon: It is not always Yaws.PLoS neglected tropical diseases · 2021Article
- Article
- Factors associated with cutaneous ulcers among children in two yaws-endemic districts in Ghana.Infectious diseases of poverty · 2020Article
- Interactions of the Skin PathogenFrontiers in immunology · 2020Review
- Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 6 countries.
Funding
Abstract
backgroundHaemophilus ducreyi and Treponema pallidum subsp. pertenue are major causes of leg ulcers in children in Africa and the Pacific Region. We investigated the presence of DNA (PCR positivity) from these bacteria on asymptomatic people, flies, and household linens in an endemic setting. METHODOLOGY/PRINCIPAL
findingsWe performed a cross-sectional study in rural villages of Lihir Island, Papua New Guinea during a yaws elimination campaign. Participants were asymptomatic subjects recruited from households with cases of leg ulcers, and from households without cases of leg ulcers. We rubbed swabs on the intact skin of the leg of asymptomatic individuals, and collected flies and swabs of environmental surfaces. All specimens were tested by PCR for H. ducreyi and T. p. pertenue DNA. Of 78 asymptomatic participants that had an adequate specimen for DNA detection, H. ducreyi-PCR positivity was identified in 16 (21%) and T. p. pertenue-PCR positivity in 1 (1%). In subgroup analyses, H. ducreyi-PCR positivity did not differ in participants exposed or not exposed to a case of H. ducreyi ulcer in the household (24% vs 18%; p = 0.76). Of 17 cultures obtained from asymptomatic participants, 2 (12%) yielded a definitive diagnosis of H. ducreyi, proving skin colonization. Of 10 flies tested, 9 (90%) had H. ducreyi DNA and 5 (50%) had T. p. pertenue DNA. Of 6 bed sheets sampled, 2 (33%) had H. ducreyi DNA and 1 (17%) had T. p. pertenue DNA. CONCLUSIONS/SIGNIFICANCE: This is the first time that H. ducreyi DNA and colonization has been demonstrated on the skin of asymptomatic children and that H. ducreyi DNA and T. p. pertenue DNA has been identified in flies and on fomites. The ubiquity of H. ducreyi in the environment is a contributing factor to the spread of the organism.
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