Evidence map›Paper›PMID 28489550›Full record

ArticleIEEE transactions on biomedical circuits and systems2017

A Fully Integrated Wireless SoC for Motor Function Recovery After Spinal Cord Injury.

Yi-Kai Lo, Yen-Cheng Kuan, Stanislav Culaclii, Brian Kim, Po-Min Wang, Chih-Wei Chang, Jonathan A Massachi, Minji Zhu, Kuanfu Chen, Parag Gad and 2 more

Abstract read
In one paragraph

Article in IEEE transactions on biomedical circuits and systems, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 69 citations in OpenAlex.

  1. Trial
  2. Review
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  9. Review
  10. A Software-Defined Radio Receiver for Wireless Recording From Freely Behaving Animals.IEEE transactions on biomedical circuits and systems · 2019
    Article
  11. Article
  12. Article
  13. A Novel Biomimetic Stimulator System for Neural Implant.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2019
    Article
  14. Article
  15. A 15-channel 30-V Neural Stimulator for Spinal Cord Repair.IEEE transactions on very large scale integration (VLSI) systems · 2018
    Article
  16. Article
  17. Article
  18. Towards Closed-Loop Neuromodulation: A Wireless Miniaturized Neural Implant SoC.Proceedings of SPIE--the International Society for Optical Engineering · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Yi-Kai Lo
Yen-Cheng Kuan
Stanislav Culaclii
Brian Kim
Po-Min Wang
Chih-Wei Chang
Jonathan A Massachi
Minji Zhu
Kuanfu Chen
Parag Gad
V Reggie Edgerton
Wentai Liu
University of California, Los Angeles · USNational Yang Ming Chiao Tung University · TW

Funding

Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCIR01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE · 2008 to 2013
$4.9M
Spinal Epidural Electrode Array To Facilitate Standing and Stepping After SCIU01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE, GAD, PARAG · 2014 to 2018
$4.8M
Novel Ultra-Flexible Hybrid Circuits for Intraocular Retinal ProsthesesR42EY018794 · NEI · PREMITEC, INC. · PI WEILAND, JAMES D. · 2013 to 2016
$1.4M
NEI NIH HHS R42 EY018794NIBIB NIH HHS R01 EB007615NIBIB NIH HHS U01 EB007615
6 · The paper itself

Abstract

This paper presents a wirelessly powered, fully integrated system-on-a-chip (SoC) supporting 160-channel stimulation, 16-channel recording, and 48-channel bio-impedance characterization to enable partial motor function recovery through epidural spinal cord electrical stimulation. A wireless transceiver is designed to support quasi full-duplex data telemetry at a data rate of 2 Mb/s. Furthermore, a unique in situ bio-impedance characterization scheme based on time-domain analysis is implemented to derive the Randles cell electrode model of the electrode-electrolyte interface. The SoC supports concurrent stimulation and recording while the high-density stimulator array meets an output compliance voltage of up to ±10 V with versatile stimulus programmability. The SoC consumes 18 mW and occupies a chip area of 5.7 mm × 4.4 mm using 0.18 μm high-voltage CMOS process. In our in vivo rodent experiment, the SoC is used to perform wireless recording of EMG responses while stimulation is applied to enable the standing and stepping of a paralyzed rat. To facilitate the system integration, a novel thin film polymer packaging technique is developed to provide a heterogeneous integration of the SoC, coils, discrete components, and high-density flexible electrode array, resulting in a miniaturized prototype implant with a weight and form factor of 0.7 g and 0.5 cm

Indexed as

Prostheses and ImplantsRecovery of FunctionSpinal Cord InjuriesWireless TechnologyAnimalsElectrodesElectromyographyEquipment DesignRatsTelemetry

Identifiers

PMID28489550
PMCPMC5562024
OpenAlexW2611776737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.