ArticleEcology letters2017
Infection of the fittest: devil facial tumour disease has greatest effect on individuals with highest reproductive output.
Article in Ecology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Host genetic diversity limits parasite success beyond agricultural systems: a meta-analysis.Proceedings. Biological sciences · 2019Pooled it
- Adaptive potential in the face of a transmissible cancer in Tasmanian devils.Molecular ecology · 2024Article
- Intergenomic signatures of coevolution between Tasmanian devils and an infectious cancer.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- In vitro competition between two transmissible cancers and potential implications for their host, the Tasmanian devil.Evolutionary applications · 2024Article
- Complex associations between cancer progression and immune gene expression reveals early influence of transmissible cancer on Tasmanian devils.Frontiers in immunology · 2024Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Transmissible cancer influences immune gene expression in an endangered marsupial, the Tasmanian devil (Sarcophilus harrisii).Molecular ecology · 2022Article
- Saving the Devils Is in the Details: Tasmanian Devil Facial Tumor Disease Can Be Eliminated with Interventions.Letters in biomathematics · 2022Article
- Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity.Pathogens (Basel, Switzerland) · 2021Article
- Spatial variation in gene expression of Tasmanian devil facial tumors despite minimal host transcriptomic response to infection.BMC genomics · 2021Article
- Infectious disease and sickness behaviour: tumour progression affects interaction patterns and social network structure in wild Tasmanian devils.Proceedings. Biological sciences · 2020Article
- Emerging infectious disease and the challenges of social distancing in human and non-human animals.Proceedings. Biological sciences · 2020Review
- The ecology and evolution of wildlife cancers: Applications for management and conservation.Evolutionary applications · 2020Article
- Changes in spatial organization following an acute epizootic: Tasmanian devils and their transmissible cancer.Global ecology and conservation · 2020Article
- A Devil of a Transmissible Cancer.Tropical medicine and infectious disease · 2020Review
- The evolution of resistance and tolerance as cancer defences.Parasitology · 2020Article
- Tracing the rise of malignant cell lines: Distribution, epidemiology and evolutionary interactions of two transmissible cancers in Tasmanian devils.Evolutionary applications · 2019Article
- Behavioural ecology and infectious disease: implications for conservation of biodiversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Individual and temporal variation in pathogen load predicts long-term impacts of an emerging infectious disease.Ecology · 2019Article
- Conserving adaptive potential: lessons from Tasmanian devils and their transmissible cancer.Conservation genetics (Print) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Emerging infectious diseases rarely affect all members of a population equally and determining how individuals' susceptibility to infection is related to other components of their fitness is critical to understanding disease impacts at a population level and for predicting evolutionary trajectories. We introduce a novel state-space model framework to investigate survival and fecundity of Tasmanian devils (Sarcophilus harrisii) affected by a transmissible cancer, devil facial tumour disease. We show that those devils that become host to tumours have otherwise greater fitness, with higher survival and fecundity rates prior to disease-induced death than non-host individuals that do not become infected, although high tumour loads lead to high mortality. Our finding that individuals with the greatest reproductive value are those most affected by the cancer demonstrates the need to quantify both survival and fecundity in context of disease progression for understanding the impact of disease on wildlife populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.