ArticleDepression and anxiety2017
The role of family history of depression and the menopausal transition in the development of major depression in midlife women: Study of women's health across the nation mental health study (SWAN MHS).
Article in Depression and anxiety, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Vasomotor Symptoms and Their Association with Depressive and Anxiety Symptoms in Peri- and Postmenopausal Women: A Systematic Review of Observational Studies.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Risk factors for perimenopausal depression in Chinese women: a meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Complex associations of adverse childhood and adulthood experiences with incident depressive symptoms in middle-aged and older Chinese adults.BMC psychology · 2026Article
- Progress and challenges in exploring the pathogenesis of depressive disorders via RNA sequencing.Frontiers in genetics · 2026Review
- Longitudinal patterns and group heterogeneity of depressive symptoms during menopausal transition in middle-aged Korean women.Epidemiology and psychiatric sciences · 2025Article
- Maintaining Balance: Examining Mental Wellness in Black Women During the Menopausal Transition.Journal of racial and ethnic health disparities · 2025Article
- Associations between menopause and body image.Przeglad menopauzalny = Menopause review · 2025Article
- Gender differences in prevalence and clinical correlates of anxiety in first-episode and drug-naïve patients with major depressive disorder comorbid with metabolic syndrome.BMC psychiatry · 2024Article
- Key Findings from Mental Health Research During the Menopause Transition for Racially and Ethnically Minoritized Women Living in the United States: A Scoping Review.Journal of women's health (2002) · 2024Article
- Depression and anxiety in peruvian military personnel during the pandemic context: a cross-sectional study.BMC public health · 2023Article
- Decreased GABA+ Levels in the Medial Prefrontal Cortex of Perimenopausal Women: A 3T 1H-MRS Study.The international journal of neuropsychopharmacology · 2023Article
- Depression in women in climacteric period: a brief review.Revista da Associacao Medica Brasileira (1992) · 2023Review
- Prevalence and predictors of depressive symptoms among married Egyptian women: a multicenter primary healthcare study.BMC psychiatry · 2022Article
- Depressive symptoms and suicidality by menopausal stages among middle-aged Korean women.Epidemiology and psychiatric sciences · 2022Article
- Biopsychosocial risk factors of depression during menopause transition in southeast China.BMC women's health · 2022Article
- A comparative magnetic resonance spectroscopy study of GABA+ and glutamate referenced to creatine and phosphocreatine in the left dorsolateral prefrontal cortex of perimenopausal women and women of reproductive age.Frontiers in psychiatry · 2022Article
- Comparative safety and efficacy of tibolone and escitalopram in postmenopausal women.Industrial psychiatry journal · 2021Article
- Depressive Symptoms and Healthy Behavior Frequency in Polish Postmenopausal Women from Urban and Rural Areas.International journal of environmental research and public health · 2021Article
- Decreased Medial Prefrontal Cortex Glutamate Levels in Perimenopausal Women.Frontiers in psychiatry · 2021Article
- Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress.BMC complementary medicine and therapies · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis study evaluated whether family history of depression predicts major depression in midlife women above and beyond static risk factors (such as personal history of depression prior to midlife) and risks that may change dynamically across midlife (such as menopausal, psychosocial, and health profiles).
methodsParticipants were 303 African American and Caucasian women (42-52 years at baseline) recruited into the Study of Women's Health across the Nation (SWAN) Mental Health Study (MHS) in Pittsburgh. Major depression was assessed annually with Structured Clinical Interviews for DSM-IV. Family mental health history was collected at the ninth or tenth annual follow-up. Random effects logistic regression was used to assess the relationship between family history of depression and midlife depression, controlling for baseline sociodemographic characteristics and time-varying risk factors.
resultsFamily history of depression was associated with midlife depression after adjusting for participant's history of major depression prior to midlife, trait anxiety and baseline age, and time-varying menopausal status, body mass index, very upsetting life events, and chronic difficulties (OR = 2.24, 95% CI = 1.17-4.29, P = .02). Higher odds of major depression were found when women were late perimenopausal or postmenopausal relative to when they were premenopausal or early perimenopausal (OR = 3.01, 95% CI = 1.76-5.15, P < .0001). However, menopausal status was only associated with major depression among women without a family history.
conclusionsFamily history of depression predicts major depression in midlife women independent of the menopausal transition and other time-varying covariates. Notably, the menopausal transition was associated with increased risk only among women without a family history of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.