ArticleDepression and anxiety2017
Fear learning alterations after traumatic brain injury and their role in development of posttraumatic stress symptoms.
Article in Depression and anxiety, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Moving beyond gender: a systematic review of diversity data gaps in prospective trauma research.European journal of psychotraumatology · 2025Pooled it
- A closed-head, rotational traumatic brain injury model demonstrates deficits in righting reflex, neurological function, and auditory brainstem responses in rats.Brain injury · 2026Article
- Transdiagnostic neural correlates of post-traumatic stress disorder and mild traumatic brain injury.Brain communications · 2026Article
- Mild Traumatic Brain Injury Impairs Fear Extinction and Network Excitability in the Infralimbic Cortex.Journal of neurotrauma · 2025Article
- Perceived neighborhood crime and gun carrying behavior: examining the role of a history of traumatic brain injury.Injury epidemiology · 2025Article
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Increased Fear Generalization and Amygdala AMPA Receptor Proteins in Chronic Traumatic Brain Injury.Journal of neurotrauma · 2022Article
- Role of Inflammation in Traumatic Brain Injury-Associated Risk for Neuropsychiatric Disorders: State of the Evidence and Where Do We Go From Here.Biological psychiatry · 2022Review
- Emotion Dysregulation Following Trauma: Shared Neurocircuitry of Traumatic Brain Injury and Trauma-Related Psychiatric Disorders.Biological psychiatry · 2022Review
- Neurobiological mechanisms underlying delayed expression of posttraumatic stress disorder: A scoping review.World journal of psychiatry · 2022Article
- Prospective examination of pre-trauma anhedonia as a risk factor for post-traumatic stress symptoms.European journal of psychotraumatology · 2022Article
- Alterations in the Topology of Functional Connectomes Are Associated with Post-Traumatic Stress Disorder and Blast-Related Mild Traumatic Brain Injury in Combat Veterans.Journal of neurotrauma · 2021Article
- Dissociable impact of childhood trauma and deployment trauma on affective modulation of startle.Neurobiology of stress · 2021Article
- A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury.Frontiers in behavioral neuroscience · 2021Review
- Impact of ADCYAP1R1 genotype on longitudinal fear conditioning in children: interaction with trauma and sex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Blast-Related Mild TBI Alters Anxiety-Like Behavior and Transcriptional Signatures in the Rat Amygdala.Frontiers in behavioral neuroscience · 2020Article
- Time Processing, Interoception, and Insula Activation: A Mini-Review on Clinical Disorders.Frontiers in psychology · 2020Review
- A Review of the Relationship Between Emotional Learning and Memory, Sleep, and PTSD.Current psychiatry reports · 2019Review
- Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity.Frontiers in neuroscience · 2019Article
- Sleep disturbance at pre-deployment is a significant predictor of post-deployment re-experiencing symptoms.European journal of psychotraumatology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIt is unknown how traumatic brain injury (TBI) increases risk for posttraumatic stress disorder (PTSD). One potential mechanism is via alteration of fear-learning processes that could affect responses to trauma memories and cues. We utilized a prospective, longitudinal design to determine if TBI is associated with altered fear learning and extinction, and if fear processing mediates effects of TBI on PTSD symptom change.
methodsEight hundred fifty two active-duty Marines and Navy Corpsmen were assessed before and after deployment. Assessments included TBI history, PTSD symptoms, combat trauma and deployment stress, and a fear-potentiated startle task of fear acquisition and extinction. Startle response and self-reported expectancy and anxiety served as measures of fear conditioning, and PTSD symptoms were measured with the Clinician-Administered PTSD Scale.
resultsIndividuals endorsing "multiple hit" exposure (both deployment TBI and a prior TBI) showed the strongest fear acquisition and highest fear expression compared to groups without multiple hits. Extinction did not differ across groups. Endorsing a deployment TBI was associated with higher anxiety to the fear cue compared to those without deployment TBI. The association of deployment TBI with increased postdeployment PTSD symptoms was mediated by postdeployment fear expression when recent prior-TBI exposure was included as a moderator. TBI associations with increased response to threat cues and PTSD symptoms remained when controlling for deployment trauma and postdeployment PTSD diagnosis.
conclusionsDeployment TBI, and multiple-hit TBI in particular, are associated with increases in conditioned fear learning and expression that may contribute to risk for developing PTSD symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.