Evidence map›Paper›PMID 28489260›Full record

ArticleLasers in surgery and medicine2017

Histologic changes associated with talaporfin sodium-mediated photodynamic therapy in rat skin.

Wesley J Moy, Jonathan Yao, Sébastien M de Feraudy, Sean M White, Jocelynda Salvador, Kristen M Kelly, Bernard Choi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in surgery and medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wesley J MoyBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
Jonathan YaoDepartment of Dermatology, University of California, Irvine, California.
Sébastien M de FeraudyDepartment of Dermatology, University of California, Irvine, California.
Sean M WhiteBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
Jocelynda SalvadorBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
Kristen M KellyBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
Bernard ChoiBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
University of California, Irvine · USIrvine University · US

Funding

Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI TROMBERG, BRUCE J. · 2012 to 2017
$7.0M
Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
Novel Optical Treatment Approach for Vascular BirthmarksR01HD065536 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHOI, BERNARD, KELLY, KRISTEN M · 2010 to 2014
$1.4M
NCATS NIH HHS KL2 TR001416NIBIB NIH HHS P41 EB015890NICHD NIH HHS R01 HD065536
6 · The paper itself

Abstract

BACKGROUND AND

objectiveAlternative treatments are needed to achieve consistent and more complete port wine stain (PWS) removal, especially in darker skin types; photodynamic therapy (PDT) is a promising alternative treatment. To this end, we previously reported on Talaporfin Sodium (TS)-mediated PDT. It is essential to understand treatment tissue effects to design a protocol that will achieve selective vascular injury without ulceration and scarring. The objective of this work is to assess skin changes associated with TS-mediated PDT with clinically relevant treatment parameters. STUDY DESIGN/MATERIALS AND

methodsWe performed TS (0.75 mg/kg)-mediated PDT (664 nm) on Sprague Dawley rats. Radiant exposures were varied between 15 and 100 J/cm

resultsTS-mediated PDT at 0.75 mg/kg combined with 15 and 25 J/cm

conclusionTS-mediated PDT can cause selective vascular injury; however, at higher light doses, significant extra-vascular injury was observed. This information can be used to contribute to design of safe protocols to be used for treatment of cutaneous vascular lesions. Lasers Surg. Med. 49:767-772, 2017. © 2017 Wiley Periodicals, Inc.

Indexed as

AnimalsLasers, SemiconductorMalePhotochemotherapyPhotosensitizing AgentsPorphyrinsPort-Wine StainRatsRats, Sprague-DawleySkinPhotosensitizing AgentsPorphyrinsTalaporfincoagulative necrosisdepth of photo-injuryNPe6photochemicalport-wine stains

Identifiers

PMID28489260
PMCPMC5603362
OpenAlexW2611990295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.