Evidence map›Paper›PMID 28489077›Full record

ArticleNature communications2017

Heterodimerization of Munc13 C

Marcial Camacho, Jayeeta Basu, Thorsten Trimbuch, Shuwen Chang, Cristina Pulido-Lozano, Shwu-Shin Chang, Irina Duluvova, Masin Abo-Rady, Josep Rizo, Christian Rosenmund

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 100 citations in OpenAlex.

  1. Article
  2. The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Munc13 serves as a molecular filter for SNARE sorting and assembly in active zone condensates.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
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  7. Article
  8. A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Diacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Molecular definition of distinct active zone protein machineries for CabioRxiv : the preprint server for biology · 2023
    Article
  18. Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Journal of neurology, neurosurgery, and psychiatry · 2023
    Review
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Marcial CamachoInstitute of Neurophysiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Jayeeta BasuDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA.
Thorsten TrimbuchInstitute of Neurophysiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Shuwen ChangInstitute of Neurophysiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Cristina Pulido-LozanoInstitute of Neurophysiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Shwu-Shin ChangDepartments of Biophysics, Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Irina DuluvovaDepartments of Biophysics, Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Masin Abo-RadyInstitute of Neurophysiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Josep RizoDepartments of Biophysics, Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Christian RosenmundInstitute of Neurophysiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.ORCID 0000-0002-3905-2444
Charité - Universitätsmedizin Berlin · DEBaylor College of Medicine · USThe University of Texas Southwestern Medical Center · US

Funding

Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0M
NINDS NIH HHS R35 NS097333
6 · The paper itself

Abstract

The presynaptic active zone protein Munc13 is essential for neurotransmitter release, playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C

Indexed as

AnimalsBinding SitesCells, CulturedHEK293 CellsHippocampusHumansIntracellular Signaling Peptides and ProteinsMice, KnockoutMicroscopy, Electron, TransmissionNerve Tissue ProteinsNeuronsProtein DomainsProtein MultimerizationSynaptic TransmissionSynaptic VesiclesIntracellular Signaling Peptides and ProteinsNerve Tissue ProteinsUnc13a protein, mouseUnc13b protein, mouse

Identifiers

PMID28489077
PMCPMC5436228
OpenAlexW2613882793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.