Evidence map›Paper›PMID 28489061›Full record

ArticleViruses2017

Microbial Natural Product Alternariol 5-O-Methyl Ether Inhibits HIV-1 Integration by Blocking Nuclear Import of the Pre-Integration Complex.

Jiwei Ding, Jianyuan Zhao, Zhijun Yang, Ling Ma, Zeyun Mi, Yanbing Wu, Jiamei Guo, Jinmin Zhou, Xiaoyu Li, Ying Guo and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Jiwei DingInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. jiweiding1223@aliyun.com.
Jianyuan ZhaoInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. zjyuan815@163.com.
Zhijun YangSchool of Pharmacy, Shanghai Jiaotong University, Shanghai 200040, China. yangzjun80@sina.com.
Ling MaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. maling26@163.com.
Zeyun MiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. mizeyun@126.com.
Yanbing WuInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. wyblily@sina.com.
Jiamei GuoInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. guojiamei@imm.ac.cn.
Jinmin ZhouInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. zhou_jim@hotmail.com.
Xiaoyu LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. xiaoyulik@hotmail.com.
Ying GuoInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. yingguo6@imm.ac.cn.
Zonggen PengInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. pumcpzg@126.com.
Tao WeiDepartment of Food Science, Beijing Union University, Beijing 100101, China. weitao@buu.edu.cn.
Haisheng YuInstitute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. yuhaisheng@moon.ibp.ac.cn.
Liguo ZhangInstitute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. zhanglgf@hotmail.com.
Mei GeSchool of Pharmacy, Shanghai Jiaotong University, Shanghai 200040, China. hccbred@gmail.com.
Shan CenInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China. shancen@imb.pumc.edu.cn.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNChinese Academy of Sciences · CNShanghai Jiao Tong University · CNBeijing Union University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While Highly Active Antiretroviral Therapy (HAART) has significantly decreased the mortality of human immunodeficiency virus (HIV)-infected patients, emerging drug resistance to approved HIV-1 integrase inhibitors highlights the need to develop new antivirals with novel mechanisms of action. In this study, we screened a library of microbial natural compounds from endophytic fungus

Indexed as

Active Transport, Cell NucleusAnti-HIV AgentsBenzopyransBiological ProductsCell LineCell NucleusColletotrichumDNA, ViralHIV-1HIV Integrase InhibitorsHumansRaltegravir PotassiumReal-Time Polymerase Chain ReactionSmall Molecule LibrariesVirus IntegrationVirus Replicationalternariol-5-O-methyl etherAnti-HIV AgentsBenzopyransBiological ProductsDNA, ViralHIV Integrase InhibitorsRaltegravir PotassiumSmall Molecule Librariesalternariol 5-O-methyl etherHIV integrationnatural productnuclear importpre-integration complex

Identifiers

PMID28489061
PMCPMC5454418
OpenAlexW2613462380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.