ArticleBlood transfusion = Trasfusione del sangue2017
Temperature-dependent haemolytic propensity of CPDA-1 stored red blood cells vs whole blood - Red cell fragility as donor signature on blood units.
Article in Blood transfusion = Trasfusione del sangue, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- The resurgence of whole blood transfusion: Evaluating microcirculatory evidence in hemorrhagic trauma care: A review.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2026Review
- The effect on canine erythrocyte osmotic fragility under different temperature variations and storage times.BMC veterinary research · 2025Article
- Evaluation of the analytical performance of four different manufacturer's reagent red blood cells in antibody detection and identification.BMC research notes · 2024Article
- Intelligent berberine-loaded erythrocytes attenuated inflammatory cytokine productions in macrophages.Scientific reports · 2024Article
- Evaluation of IgG and Complement Component C4 Levels in Low-Income Countries, Yemen Republic in Light of Their Proposed Role in the Hemolysis of Stored CPDA-1 Whole Blood.Journal of blood medicine · 2024Article
- In vitro quality and hemostatic function of cold-stored CPDA-1 whole blood after repeated transient exposure to 28°C storage temperature.Transfusion · 2022Article
- The effect of blood viscosity on shear-induced hemolysis using a magnetically levitated shearing device.Artificial organs · 2022Article
- Deciphering the Relationship Between Free and Vesicular Hemoglobin in Stored Red Blood Cell Units.Frontiers in physiology · 2022Article
- Beta thalassemia minor is a beneficial determinant of red blood cell storage lesion.Haematologica · 2022Article
- Effects of leukoreduction on storage lesions in whole blood and blood components of dogs.Journal of veterinary internal medicine · 2021Article
- Red Blood Cell Abnormalities as the Mirror of SARS-CoV-2 Disease Severity: A Pilot Study.Frontiers in physiology · 2021Article
- Whole Blood Storage in CPDA1 Blood Bags Alters Erythrocyte Membrane Proteome.Oxidative medicine and cellular longevity · 2018Article
- Redox Status, Procoagulant Activity, and Metabolome of Fresh Frozen Plasma in Glucose 6-Phosphate Dehydrogenase Deficiency.Frontiers in medicine · 2018Article
- Metabolic Linkage and Correlations to Storage Capacity in Erythrocytes from Glucose 6-Phosphate Dehydrogenase-Deficient Donors.Frontiers in medicine · 2017Article
- Exposure of red blood cell concentrates to temperatures below 0°C for a short period does not alter in vitro quality.Blood transfusion = Trasfusione del sangueArticle
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo preserve cellular integrity and avoid bacterial growth, storage and transfer of blood and blood products follow strict guidelines in terms of temperature control. We evaluated the impact of ineligible warming of whole blood donations on the quality of blood components. MATERIALS AND
methodsOne-hundred and twenty units of whole blood (WB) from eligible blood donors were collected in CPDA-1 and stored at 4±2 °C. During shipment to the blood processing centre, a gradual warming up to 17 °C was recorded within a period of less than eight hours. The warmed units were processed to packed red blood cells (PRBCs) or stored as WB units at 4±2 °C. In-bag haemolysis, osmotic fragility (mean corpuscular fragility, MCF) and bacterial growth were assessed in blood and blood components throughout the storage period.
resultsNormal basal and early storage levels of haemolysis were recorded in both PRBC and WB units. Thereafter, PRBCs exhibited higher average in-bag haemolysis and MCF index compared to the WB units throughout the storage. Moreover, 14.3 and 52.4% of the PRBC units exceeded the upper permissible limit of 0.8% haemolysis at the middle (1.220±0.269%) or late (1.754±0.866%) storage period, respectively. MCF index was similar in all PRBCs at the middle of storage but significantly lower in the non-haemolysed compared to the haemolysed units of PRBCs on the last days. The fragility of stored RBCs was proportional to the donor-related values of day 2 samples (r=0.861, p<10 DISCUSSION: Transient, gradient warming of whole blood from 4 to 17 °C led to increased incidence of in-bag haemolysis in PRBC but not in WB units. Haemolysis is a multi-parametric phenotype of stored blood, and MCF is a donor-related and highly dynamic measure that can, in part, predict the storage lesion.
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