ArticleBiochemistry2017
Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.
Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Tracking protein-protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochromePhysical chemistry chemical physics : PCCP · 2024Article
- Redox partner recognition and selectivity of cytochrome P450lin (CYP111A1).Journal of inorganic biochemistry · 2023Article
- Conformational heterogeneity suggests multiple substrate binding modes in CYP106A2.Journal of inorganic biochemistry · 2023Article
- Engineering sequence and selectivity of late-stage C-H oxidation in the MycG iterative cytochrome P450.Journal of industrial microbiology & biotechnology · 2022Article
- A dynamic understanding of cytochrome P450 structure and function through solution NMR.Current opinion in biotechnology · 2021Review
- An overview of the cytochrome P450 enzymes that catalyze the same-site multistep oxidation reactions in biotechnologically relevant selected actinomycete strains.Applied microbiology and biotechnology · 2021Review
- Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics.Journal of the American Chemical Society · 2020Article
- Molecular basis for the P450-catalyzed C-N bond formation in indolactam biosynthesis.Nature chemical biology · 2019Article
- What Your Crystal Structure Will Not Tell You about Enzyme Function.Accounts of chemical research · 2019Article
- Entropic contribution to enhanced thermal stability in the thermostable P450 CYP119.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Some Surprising Implications of NMR-directed Simulations of Substrate Recognition and Binding by Cytochrome P450Journal of molecular biology · 2018Article
- Approaches and Recent Developments for the Commercial Production of Semi-synthetic Artemisinin.Frontiers in plant science · 2018Review
- Substrate recognition by two different P450s: Evidence for conserved roles in a common fold.Scientific reports · 2017Article
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Authors and funding
4 authors.
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Abstract
MycG is a P450 monooxygenase that catalyzes the sequential hydroxylation and epoxidation of mycinamicin IV (M-IV), the last two steps in the biosynthesis of mycinamicin II, a macrolide antibiotic isolated from Micromonospora griseorubida. The crystal structure of MycG with M-IV bound was previously determined but showed the bound substrate in an orientation that did not rationalize the observed regiochemistry of M-IV hydroxylation. Nuclear magnetic resonance paramagnetic relaxation enhancements provided evidence of an orientation of M-IV in the MycG active site more compatible with the observed chemistry, but substrate-induced changes in the enzyme structure were not characterized. We now describe the use of amide
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